Gene name
HPN (TMPRSS1)
Experiment(s)
For this entry:
HEPS_MOUSE (HPN)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Brunati M,Perucca S,Han L,Cattaneo A,Consolato F,Andolfo A,Schaeffer C,Olinger E,Peng J,Santambrogio S,Perrier R,Li S,Bokhove M,Bachi A,Hummler E,Devuyst O,Wu Q,Jovine L,Rampoldi L (2015) The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin., Elife, 4, e08887. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Henle's loop / TAL cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 36 | Cytoplasmic |
| 37 | 59 | Membrane |
| 60 | 436 | Extracellular |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Hepsin |
| InterPro | Hepsin-SRCR_dom |
| InterPro | Peptidase_S1_PA |
| InterPro | Peptidase_S1_PA_chymotrypsin |
| InterPro | Peptidase_S1A |
| InterPro | SRCR-like_dom |
| InterPro | SRCR-like_dom_sf |
| InterPro | Trypsin_dom |
| InterPro | TRYPSIN_HIS |
| InterPro | TRYPSIN_SER |
| Pfam | Hepsin-SRCR |
| Pfam | Trypsin |