Gene name
Slc2a5 (Glut5)
Experiment(s)
For this entry:
GTR5_RAT (Slc2a5)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Inukai K,Shewan AM,Pascoe WS,Katayama S,James DE,Oka Y (2004) Carboxy terminus of glucose transporter 3 contains an apical membrane targeting domain., Mol Endocrinol, 18, 339-49. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
GTR5_RAT (Slc2a5)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Inukai K,Takata K,Asano T,Katagiri H,Ishihara H,Nakazaki M,Fukushima Y,Yazaki Y,Kikuchi M,Oka Y (1997) Targeting of GLUT1-GLUT5 chimeric proteins in the polarized cell line Caco-2., Mol Endocrinol, 11, 442-9. [PubMed] [DOI] |
| Evidence level | Antibody staining + sub-protein manipulation |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes | The large intracellular loop was identified as a determinat of sorting |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 18 | Cytoplasmic |
| 19 | 40 | Membrane |
| 41 | 70 | Extracellular |
| 71 | 91 | Membrane |
| 92 | 98 | Cytoplasmic |
| 99 | 118 | Membrane |
| 119 | 125 | Extracellular |
| 126 | 146 | Membrane |
| 147 | 160 | Cytoplasmic |
| 161 | 180 | Membrane |
| 181 | 192 | Extracellular |
| 193 | 212 | Membrane |
| 213 | 277 | Cytoplasmic |
| 278 | 298 | Membrane |
| 299 | 314 | Extracellular |
| 315 | 335 | Membrane |
| 336 | 342 | Cytoplasmic |
| 343 | 361 | Membrane |
| 362 | 374 | Extracellular |
| 375 | 396 | Membrane |
| 397 | 410 | Cytoplasmic |
| 411 | 432 | Membrane |
| 433 | 439 | Extracellular |
| 440 | 459 | Membrane |
| 460 | 502 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Fru_transpt_5 |
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Sugar/inositol_transpt |
| InterPro | Sugar_transporter_CS |
| Pfam | Sugar_tr |