Gene name
SLC2A3 (GLUT3,LOC100909595)
Experiment(s)
For this entry:
GTR3_HUMAN (SLC2A3)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Inukai K,Shewan AM,Pascoe WS,Katayama S,James DE,Oka Y (2004) Carboxy terminus of glucose transporter 3 contains an apical membrane targeting domain., Mol Endocrinol, 18, 339-49. [PubMed] [DOI] |
| Evidence level | Antibody staining + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | The sequence DRSGKDGVMEMN preceding the PDZ motif was identified as the apical determinant |
GTR3_HUMAN (SLC2A3)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Núñez MT,Tapia V,Rojas A,Aguirre P,Gómez F,Nualart F (2010) Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1., Am J Physiol Cell Physiol, 298, C477-85. [PubMed] [DOI] |
| Evidence level | Other |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes | A membrane side-specific biotinylation and purification scheme was followed |
GTR3_HUMAN (SLC2A3)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Harris DS,Slot JW,Geuze HJ,James DE (1992) Polarized distribution of glucose transporter isoforms in Caco-2 cells., Proc Natl Acad Sci U S A, 89, 7556-60. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes | Endogenous proteins |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 11 | Cytoplasmic |
| 12 | 33 | Membrane |
| 34 | 63 | Extracellular |
| 64 | 85 | Membrane |
| 86 | 91 | Cytoplasmic |
| 92 | 111 | Membrane |
| 112 | 118 | Extracellular |
| 119 | 140 | Membrane |
| 141 | 153 | Cytoplasmic |
| 154 | 172 | Membrane |
| 173 | 185 | Extracellular |
| 186 | 205 | Membrane |
| 206 | 270 | Cytoplasmic |
| 271 | 290 | Membrane |
| 291 | 306 | Extracellular |
| 307 | 326 | Membrane |
| 327 | 333 | Cytoplasmic |
| 334 | 352 | Membrane |
| 353 | 365 | Extracellular |
| 366 | 387 | Membrane |
| 388 | 402 | Cytoplasmic |
| 403 | 424 | Membrane |
| 425 | 430 | Extracellular |
| 431 | 450 | Membrane |
| 451 | 496 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 43 | N-GlycoSiteAtlas | 25285165 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Glc_transpt_3 |
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Sugar/inositol_transpt |
| InterPro | Sugar_transporter_CS |
| Pfam | Sugar_tr |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CR3L1_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.