Gene name
GPR143 (Gpr143_predicted,OA1)
Experiment(s)
For this entry:
GP143_HUMAN (GPR143)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Lopez VM,Decatur CL,Stamer WD,Lynch RM,McKay BS (2008) L-DOPA is an endogenous ligand for OA1., PLoS Biol, 6, e236. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Pigment epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 27 | Extracellular |
| 28 | 45 | Membrane |
| 46 | 72 | Cytoplasmic |
| 73 | 94 | Membrane |
| 95 | 113 | Extracellular |
| 114 | 135 | Membrane |
| 136 | 154 | Cytoplasmic |
| 155 | 176 | Membrane |
| 177 | 195 | Extracellular |
| 196 | 213 | Membrane |
| 214 | 245 | Cytoplasmic |
| 246 | 267 | Membrane |
| 268 | 292 | Extracellular |
| 293 | 314 | Membrane |
| 315 | 404 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | GPR143 |
| Pfam | Ocular_alb |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| MAR1_HUMAN | 2 | 19717472 |
| TYRO_MOUSE | 2 | 27720922 |
| TYRO_HUMAN | 4 | 27720922 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.