Gene name
GGT1 (Ggt,Ggtp)
Experiment(s)
For this entry:
GGT1_HUMAN (GGT1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Khan S,Cabral PD,Schilling WP,Schmidt ZW,Uddin AN,Gingras A,Madhavan SM,Garvin JL,Schelling JR (2018) Kidney Proximal Tubule Lipoapoptosis Is Regulated by Fatty Acid Transporter-2 (FATP2)., J Am Soc Nephrol, 29, 81-91. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
GGT1_HUMAN (GGT1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Paulusma CC,Groen A,Kunne C,Ho-Mok KS,Spijkerboer AL,Rudi de Waart D,Hoek FJ,Vreeling H,Hoeben KA,van Marle J,Pawlikowska L,Bull LN,Hofmann AF,Knisely AS,Oude Elferink RP (2006) Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport., Hepatology, 44, 195-204. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes | Apical localization depends on ATP8B1 |
For ortholog entries:
Alignment and sequence features
Loading data
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 4 | Cytoplasmic |
| 5 | 26 | Membrane |
| 27 | 569 | Extracellular |
Phosphorylation
| Position | Resource |
|---|---|
| 550 | 25293446 |
Glycosylation
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Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | GGT_lsub_C |
| InterPro | GGT_peptidase |
| InterPro | GGT_ssub |
| InterPro | Ntn_hydrolases_N |