Gene name
FSHR (LGR1)
Experiment(s)
For this entry:
FSHR_HUMAN (FSHR)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Beau I,Groyer-Picard MT,Le Bivic A,Vannier B,Loosfelt H,Milgrom E,Misrahi M (1998) The basolateral localization signal of the follicle-stimulating hormone receptor., J Biol Chem, 273, 18610-6. [PubMed] [DOI] |
| Evidence level | Antibody staining + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Basolateral localization depended in the Tyr-based YILV motif |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 17 | Signal peptide |
| 18 | 374 | Extracellular |
| 375 | 390 | Membrane |
| 391 | 399 | Cytoplasmic |
| 400 | 421 | Membrane |
| 422 | 444 | Extracellular |
| 445 | 465 | Membrane |
| 466 | 485 | Cytoplasmic |
| 486 | 506 | Membrane |
| 507 | 529 | Extracellular |
| 530 | 550 | Membrane |
| 551 | 573 | Cytoplasmic |
| 574 | 595 | Membrane |
| 596 | 608 | Extracellular |
| 609 | 629 | Membrane |
| 630 | 695 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | FSH_rcpt |
| InterPro | GnHR_TM |
| InterPro | GPCR_Rhodpsn |
| InterPro | GPCR_Rhodpsn_7TM |
| InterPro | Gphrmn_rcpt_fam |
| InterPro | LRR_5 |
| InterPro | LRRNT |
| Pfam | 7tm_1 |
| Pfam | GnHR_trans |
| Pfam | LRR_5 |
| Pfam | LRRNT |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| 1433T_HUMAN | 3 | 15196694 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.