Gene name

Fn1 (FN)

Experiment(s)

For this entry:
FINC_HUMAN (Fn1)
Species Homo sapiens
Localization Apical plasma membrane
Reference Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807.
[PubMed] [DOI]
Evidence level Large-scale proteomics
Organ Lung
Cell Airway epithel cells
Notes Only mock-transfected cells were considered
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 2477 Extracellular
Phosphorylation
Position Resource
41 56652252
101 5939952
106 15403535
112 54414084
136 25292574
372 3737059
588 23107742
641 477240
715 34505591
904 4273195
937 23107745
960 25292578
968 25292586
972 25292590
1042 18910452
1122 34734723
1206 12432456
1834 25292582
1853 23107736
1877 23107739
1924 23107730
1931 10799245
1933 10799249
1946 10799253
1951 11139362
1970 15403529
1975 15403538
2073 54414088
2349 15403532
2403 40247700
2432 50779164
2440 27449383
2441 473123
2444 473124
2445 15403541
2454 34502147
2475 467903
Glycosylation
Position Site resource Glycan resource PubMed link(s)
19 O-GlycoProteomDB
24 O-GlycoProteomDB
27 O-GlycoProteomDB
46 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
274 PolarProtDb WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1x_1-5]/1-2/a?-b1 30350625
274 O-GlycoProteomDB
275 PolarProtDb WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1x_1-5]/1-2/a?-b1 30350625
275 O-GlycoProteomDB
278 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
278 PolarProtDb WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30033600
278 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
278 PolarProtDb WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/ 29296958
278 dbPTM 55828959
278 O-GlycoProteomDB
279 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
279 PolarProtDb WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30033600
279 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
279 PolarProtDb WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/ 29296958
279 dbPTM 55828963
279 O-GlycoProteomDB
279 UniProtKB 16037490
280 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
280 PolarProtDb WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30033600
280 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
280 PolarProtDb WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/ 29296958
280 dbPTM 55828967
280 O-GlycoProteomDB
281 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
281 PolarProtDb WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30033600
281 dbPTM 55828973
281 O-GlycoProteomDB
283 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
283 PolarProtDb WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30033600
283 dbPTM 55828977
283 O-GlycoProteomDB
287 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
287 PolarProtDb WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30033600
287 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
287 PolarProtDb WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/ 29296958
287 dbPTM 55828813
287 O-GlycoProteomDB
388 O-GlycoProteomDB
389 O-GlycoProteomDB
402 O-GlycoProteomDB
410 O-GlycoProteomDB
415 UniPep
430 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 20541508
430 dbPTM 11285216 , 16037490 , 16335952
430 N-GlycoSiteAtlas 24495048
430 UniPep
430 UniProtKB 11285216 , 16037490 , 16335952
448 O-GlycoProteomDB
449 O-GlycoProteomDB
528 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 20541508
528 dbPTM 14760718 , 16037490 , 16335952 , 19139490 , 19159218
528 N-GlycoSiteAtlas 24495048
528 PolarProtDb 31844046
528 UniPep
528 UniProtKB 14760718 , 16037490 , 16335952 , 19139490 , 19159218
542 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 20541508
542 dbPTM 16037490 , 16335952 , 19139490
542 N-GlycoSiteAtlas 24495048
542 UniPep
542 UniProtKB 16037490 , 16335952 , 19139490
604 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
604 O-GlycoProteomDB
607 O-GlycoProteomDB
617 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
617 O-GlycoProteomDB
619 O-GlycoProteomDB
625 O-GlycoProteomDB
658 O-GlycoProteomDB
667 O-GlycoProteomDB
712 O-GlycoProteomDB
715 O-GlycoProteomDB
716 O-GlycoProteomDB
719 O-GlycoProteomDB
724 O-GlycoProteomDB
877 dbPTM 16037490 , 17614963
877 N-GlycoSiteAtlas 24495048
877 UniPep
877 UniProtKB 16037490 , 17614963
935 O-GlycoProteomDB
981 O-GlycoProteomDB
1007 dbPTM 16037490 , 16335952 , 19139490 , 19159218
1007 N-GlycoSiteAtlas 19159218
1007 PolarProtDb 31844046
1007 UniPep
1007 UniProtKB 16037490 , 16335952 , 19139490 , 19159218
1034 O-GlycoProteomDB
1122 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
1122 O-GlycoProteomDB
1198 O-GlycoProteomDB
1199 O-GlycoProteomDB
1200 O-GlycoProteomDB
1204 O-GlycoProteomDB
1236 N-GlycoSiteAtlas 24495048
1236 UniPep
1244 dbPTM 16037490 , 16335952
1244 N-GlycoSiteAtlas 26571101
1244 UniPep
1244 UniProtKB 16037490 , 16335952
1282 O-GlycoProteomDB
1291 UniPep
1367 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1417 N-GlycoSiteAtlas 22106898
1551 O-GlycoProteomDB
1565 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
1565 PolarProtDb WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/ 29296958
1565 dbPTM 55830715
1565 O-GlycoProteomDB
1576 O-GlycoProteomDB
1618 O-GlycoProteomDB
1656 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1657 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1658 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1661 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1732 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1828 O-GlycoProteomDB
1833 O-GlycoProteomDB
1871 O-GlycoProteomDB
1877 O-GlycoProteomDB
1892 O-GlycoProteomDB
1914 O-GlycoProteomDB
1922 O-GlycoProteomDB
1931 O-GlycoProteomDB
1999 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
1999 PolarProtDb WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/ 29296958
1999 dbPTM 55833805
1999 O-GlycoProteomDB
2061 PolarProtDb WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/ 29296958
2061 dbPTM 55826763
2061 O-GlycoProteomDB
2090 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
2090 PolarProtDb WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1x_1-5]/1-2/a?-b1 30350625
2151 PolarProtDb WURCS=2.0/3,3,2/[AUd21122h_5*NCC/3=O][uxxxxh_2*NCC/3=O][uxxxxh]/1-2-3/a?|b?|c?}-{a?|b?|c?_a?|b?|c?}-{a?|b?|c? 30033600
2151 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
2151 PolarProtDb WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/ 30350625
2151 PolarProtDb WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30033600
2151 PolarProtDb WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?|b?|c?}-{a?|b?|c?_a?|b?|c?}-{a?|b?|c? 30033600
2151 PolarProtDb WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1x_1-5]/1-2/a?-b1 30350625
2152 PolarProtDb WURCS=2.0/3,3,2/[AUd21122h_5*NCC/3=O][uxxxxh_2*NCC/3=O][uxxxxh]/1-2-3/a?|b?|c?}-{a?|b?|c?_a?|b?|c?}-{a?|b?|c? 30033600
2152 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
2152 PolarProtDb WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/ 30350625
2152 PolarProtDb WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30033600
2152 PolarProtDb WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?|b?|c?}-{a?|b?|c?_a?|b?|c?}-{a?|b?|c? 30033600
2152 PolarProtDb WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1x_1-5]/1-2/a?-b1 30350625
2155 PolarProtDb WURCS=2.0/3,3,2/[AUd21122h_5*NCC/3=O][uxxxxh_2*NCC/3=O][uxxxxh]/1-2-3/a?|b?|c?}-{a?|b?|c?_a?|b?|c?}-{a?|b?|c? 30033600
2155 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
2155 PolarProtDb WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/ 30350625
2155 PolarProtDb WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30033600
2155 PolarProtDb WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?|b?|c?}-{a?|b?|c?_a?|b?|c?}-{a?|b?|c? 30033600
2155 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
2155 PolarProtDb WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/ 29296958
2155 O-GlycoProteomDB
2156 PolarProtDb WURCS=2.0/3,3,2/[AUd21122h_5*NCC/3=O][uxxxxh_2*NCC/3=O][uxxxxh]/1-2-3/a?|b?|c?}-{a?|b?|c?_a?|b?|c?}-{a?|b?|c? 30033600
2156 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
2156 PolarProtDb WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30033600
2158 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
2158 PolarProtDb WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?|b?|c?}-{a?|b?|c?_a?|b?|c?}-{a?|b?|c? 30033600
2158 O-GlycoProteomDB
2199 UniProtKB 16037490
2341 PolarProtDb WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1 29296958
2341 dbPTM 55830961
2341 O-GlycoProteomDB
2345 dbPTM 55830967
2345 O-GlycoProteomDB
2361 O-GlycoProteomDB
2432 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
2436 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
2437 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
2440 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/

Family and domain data

Database Domain/Family name
InterPro Fibronectin_type1
InterPro FN3_dom
InterPro FN3_sf
InterPro FN_type2_dom
InterPro FN_type2_sf
InterPro Ig-like_fold
InterPro Kringle-like
Pfam fn1
Pfam fn2
Pfam fn3

Interactions

With (links to EBI) #Exp PubMed links
GSTK1_HUMAN 2 19738201
IMA1_HUMAN 2 19738201 , 21988832
RCC2_HUMAN 2 19738201
TSP1_HUMAN 2 19542224 , 18042364
ITA5_HUMAN 6 24789099 , 19738201
ITB1_HUMAN 9 24789099 , 19738201
X3CL1_HUMAN 4 24789099
ITA4_HUMAN 3 24789099 , 19738201
POLG_HCVJF 4 24136289
POLG_DEN27 2 21911577
ITB3_HUMAN 3 1694173 , 24789099
ALBU_HUMAN 3 15174051
ITAV_HUMAN 2 1694173 , 19738201
CFTR_HUMAN 8 29924966
MYC_HUMAN 2 21150319
UBQL1_HUMAN 3 25416956
TSG6_HUMAN 12 18042364
ARMS2_HUMAN 2 19696174
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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