PolarProtDb

Gene name

FCGR2B (CD32,FCG2,IGFR2)

Experiment(s)

For this entry:

FCG2B_HUMAN (FCGR2B)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Hunziker W,Fumey C (1994) A di-leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells., EMBO J, 13, 2963-9. [PubMed]
Evidence level	Membrane preparation + sub-protein manipulation
Organ	Kidney
Cell	MDCK cells (distal tubule)
Notes	The source of plasmid is not mentioned

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	42	Signal peptide
43	224	Extracellular
225	246	Membrane
247	310	Cytoplasmic

Motifs gathered by PolarProtDb Team

Start	End	Localisation	Type	PubMed
291	296	Basolateral plasma membrane	Tyrosine	Hunziker W,Fumey C (1994) A di-leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells., EMBO J, 13, 2963-9. [PubMed]

Phosphorylation

Position	Resource
292	448507
293	14568079

Glycosylation

Position	Site resource	PubMed link(s)
106	PDB	30021105
106	N-GlycoSiteAtlas	24495048
180	N-GlycoSiteAtlas	24495048
187	PDB	30021105
187	N-GlycoSiteAtlas	24495048

Family and domain data

Database	Domain/Family name
InterPro	Ig-like_dom
InterPro	Ig-like_dom_sf
InterPro	Ig-like_fold
InterPro	Ig_sub
InterPro	Ig_sub2
Pfam	Ig_2

Interactions

With (links to EBI)	#Exp	PubMed links
PLCG1_HUMAN	2	17474147
IGHG1_HUMAN	31	11567028
NCK1_HUMAN	2	17474147

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.