Gene name
SLC9B2 (LOC679958,Nhedc2,Nha2)
Experiment(s)
For this entry:
F6XZG7_CANLF (SLC9B2)
| Species | Canis lupus familiaris |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kondapalli KC,Kallay LM,Muszelik M,Rao R (2012) Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient., J Biol Chem, 287, 36239-50. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Detecting endogenous proteins |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 82 | Cytoplasmic |
| 83 | 104 | Membrane |
| 105 | 114 | Extracellular |
| 115 | 135 | Membrane |
| 136 | 145 | Cytoplasmic |
| 146 | 161 | Membrane |
| 162 | 171 | Extracellular |
| 172 | 192 | Membrane |
| 193 | 206 | Cytoplasmic |
| 207 | 227 | Membrane |
| 228 | 234 | Extracellular |
| 235 | 256 | Membrane |
| 257 | 279 | Cytoplasmic |
| 280 | 295 | Membrane |
| 296 | 302 | Extracellular |
| 303 | 324 | Membrane |
| 325 | 339 | Cytoplasmic |
| 340 | 355 | Membrane |
| 356 | 360 | Extracellular |
| 361 | 376 | Membrane |
| 377 | 387 | Cytoplasmic |
| 388 | 408 | Membrane |
| 409 | 419 | Extracellular |
| 420 | 442 | Membrane |
| 443 | 451 | Cytoplasmic |
| 452 | 472 | Membrane |
| 473 | 490 | Extracellular |
| 491 | 512 | Membrane |
| 513 | 537 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Cation/H_exchanger |
| InterPro | Na+/solute_symporter_sf |
| InterPro | SLC9B2 |
| Pfam | Na_H_Exchanger |