PolarProtDb

Gene name

ERBB3 (HER3)

Experiment(s)

For this entry:

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	20	Signal peptide
21	646	Extracellular
647	664	Membrane
665	1339	Cytoplasmic

Eukaryotic Linear Motif (ELM)

Start	End	Sequence	Motif
1120	1124	SPRPR	TRG_ER_diArg_1

Phosphorylation

Position	Resource
684	4271377
715	27450385
980	17545934
1080	17545938
1090	1868294871
1091	17545942
1094	36622820
1118	6421026
1120	451840
1156	454902
1259	3971613
1286	449858
1309	50780422
1312	22639462
1325	451650
1328	23112806

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
250	Glyconnect	$WURCS=2.0/2,9,8/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?$	30899004
250	Glyconnect	$WURCS=2.0/2,7,6/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?$	30899004
250	Glyconnect	$WURCS=2.0/2,8,7/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?$	30899004

Family and domain data

Database	Domain/Family name
InterPro	Furin-like_Cys-rich_dom
InterPro	Furin_repeat
InterPro	GF_recep_IV
InterPro	Growth_fac_rcpt_cys_sf
InterPro	Kinase-like_dom_sf
InterPro	Prot_kinase_dom
InterPro	Rcpt_L-dom
InterPro	Rcpt_L-dom_sf
InterPro	Ser-Thr/Tyr_kinase_cat_dom
InterPro	Tyr_kinase_AS
InterPro	Tyr_kinase_cat_dom
InterPro	Tyr_kinase_EGF/ERB/XmrK_rcpt
Pfam	Furin-like
Pfam	GF_recep_IV
Pfam	PK_Tyr_Ser-Thr
Pfam	Recep_L_domain