Gene name

ERBB3 (HER3)

Experiment(s)

For this entry:
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 19 Signal peptide
20 646 Extracellular
647 666 Membrane
667 1342 Cytoplasmic
Eukaryotic Linear Motif (ELM)
Start End Sequence Motif
1123 1127 SPRPR TRG_ER_diArg_1
Phosphorylation
Glycosylation
Position Site resource Glycan resource PubMed link(s)
126 N-GlycoSiteAtlas 24495048
126 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29763625
250 N-GlycoSiteAtlas 22148984 , 22106898 , 24324730 , 24741114 , 25244057 , 25247386 , 24495048 , 26571101 , 26256267
250 UniProtKB 12154198
250 PolarProtDb 31844046
250 dbPTM 12154198
250 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23780344
250 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 12154198
250 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 23928993
250 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5]/1-1-2/a4-b1_b4-c1 29763625
250 Glyconnect WURCS=2.0/2,7,6/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2/a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g?_a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g?_a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g?_a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g?_a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g?_a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g? 29741879
250 Glyconnect WURCS=2.0/2,9,8/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2/a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i? 29741879
353 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23780344
353 UniProtKB 12154198
353 N-GlycoSiteAtlas 23090970
353 dbPTM 12154198
353 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29763625
353 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29763625
353 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 12154198
353 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 23928993
353 Glyconnect WURCS=2.0/3,10,9/[Aad21122h-2x_2-6_5*NCC/3=O][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2-2-2-3-3-3-3-3-3/a?|b?|c?|d?|e?|f?|g?|h?|i?|j?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j? 29741879
353 Glyconnect WURCS=2.0/3,11,10/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-3-3-3-3-3-3/a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k? 29741879
353 Glyconnect WURCS=2.0/2,9,8/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2/a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i? 29741879
408 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23928993
408 UniProtKB 12154198
408 N-GlycoSiteAtlas 26571101
408 dbPTM 12154198
408 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29763625
408 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 29763625
408 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 23780344
408 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 12154198
414 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29763625
414 UniProtKB 12154198
414 PolarProtDb 31844046
414 N-GlycoSiteAtlas 24495048
414 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29763625
414 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23928993
414 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23780344
414 dbPTM 12154198
437 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29763625
437 UniProtKB 12154198
437 PolarProtDb 31844046
437 N-GlycoSiteAtlas 26571101
437 dbPTM 12154198
437 PDB WURCS=2.0/1,1,0/[a2122h-1a_1-5_2*NCC/3=O]/1/ 12154198
437 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29763625
437 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23928993
437 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23780344
437 Glyconnect WURCS=2.0/3,12,11/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-1-2-2-2-2-3-3-3-3-3/a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l? 29741879
469 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29763625
469 UniProtKB 12154198
469 N-GlycoSiteAtlas 24495048
469 dbPTM 12154198
469 PDB WURCS=2.0/1,1,0/[a2122h-1a_1-5_2*NCC/3=O]/1/ 12154198
469 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 29763625
522 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 12154198
522 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29763625
522 dbPTM 12154198
522 UniProtKB 12154198
566 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 12154198
566 dbPTM 12154198
566 N-GlycoSiteAtlas 26571101
566 UniPep
566 UniProtKB 12154198
616 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23780344
616 N-GlycoSiteAtlas 26571101

Family and domain data

Database Domain/Family name
InterPro Furin-like_Cys-rich_dom
InterPro Furin_repeat
InterPro GF_recep_IV
InterPro Growth_fac_rcpt_cys_sf
InterPro Kinase-like_dom_sf
InterPro Prot_kinase_dom
InterPro Rcpt_L-dom
InterPro Rcpt_L-dom_sf
InterPro Ser-Thr/Tyr_kinase_cat_dom
InterPro Tyr_kinase_EGF/ERB/XmrK_rcpt
Pfam Furin-like
Pfam GF_recep_IV
Pfam PK_Tyr_Ser-Thr
Pfam Recep_L_domain

Interactions

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