PolarProtDb

Gene name

ERBB3 (HER3)

Experiment(s)

For this entry:

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	19	Signal peptide
20	646	Extracellular
647	666	Membrane
667	1342	Cytoplasmic

Eukaryotic Linear Motif (ELM)

Start	End	Sequence	Motif
1123	1127	SPRPR	TRG_ER_diArg_1

Phosphorylation

Position	Resource
15	50323707
640	23112821
680	7445129
686	4271377
693	38483677
717	27450385
844	23112809
846	23112812
868	15281413
869	23112815
982	17545934
996	51389402
1052	50687015
1054	449859
1083	17545938
1094	17545942
1104	51389398
1113	50780418
1132	22777351
1134	38483681
1147	23112803
1159	454902
1164	22779984
1197	448640
1199	458099
1207	34501250
1215	34503838
1222	448639
1260	449860
1262	3971613
1276	449857
1285	15420102
1289	449858
1307	454901
1312	50780422
1315	22639462
1319	23112818
1328	451650
1331	23112806

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
126	N-GlycoSiteAtlas		24495048
126	PDB		29763625
250	N-GlycoSiteAtlas		22148984 , 22106898 , 24324730 , 24741114 , 25244057 , 25247386 , 24495048 , 26571101 , 26256267
250	UniProtKB		12154198
250	PolarProtDb		31844046
250	dbPTM		12154198
250	PDB		23780344
250	PDB		12154198
250	PDB		23928993
250	PDB		29763625
250	Glyconnect	$WURCS=2.0/2,7,6/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?$	29741879
250	Glyconnect	$WURCS=2.0/2,9,8/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?$	29741879
353	PDB		23780344
353	UniProtKB		12154198
353	N-GlycoSiteAtlas		23090970
353	dbPTM		12154198
353	PDB		29763625
353	PDB		29763625
353	PDB		12154198
353	PDB		23928993
353	Glyconnect	$WURCS=2.0/3,10,9/[Aad21122h-2x_2-6_5NCC/3=O][axxxxh-1x_1-5_2NCC/3=O][axxxxh-1x_1-5]/1-2-2-2-3-3-3-3-3-3/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?$	29741879
353	Glyconnect	$WURCS=2.0/3,11,10/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-3-3-3-3-3-3/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?$	29741879
353	Glyconnect	$WURCS=2.0/2,9,8/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?$	29741879
408	PDB		23928993
408	UniProtKB		12154198
408	N-GlycoSiteAtlas		26571101
408	dbPTM		12154198
408	PDB		29763625
408	PDB		29763625
408	PDB		23780344
408	PDB		12154198
414	PDB		29763625
414	UniProtKB		12154198
414	PolarProtDb		31844046
414	N-GlycoSiteAtlas		24495048
414	PDB		29763625
414	PDB		23928993
414	PDB		23780344
414	dbPTM		12154198
437	PDB		29763625
437	UniProtKB		12154198
437	PolarProtDb		31844046
437	N-GlycoSiteAtlas		26571101
437	dbPTM		12154198
437	PDB		12154198
437	PDB		29763625
437	PDB		23928993
437	PDB		23780344
437	Glyconnect	$WURCS=2.0/3,12,11/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-1-2-2-2-2-3-3-3-3-3/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?\|l?$	29741879
469	PDB		29763625
469	UniProtKB		12154198
469	N-GlycoSiteAtlas		24495048
469	dbPTM		12154198
469	PDB		12154198
469	PDB		29763625
522	PDB		12154198
522	PDB		29763625
522	dbPTM		12154198
522	UniProtKB		12154198
566	PDB		12154198
566	dbPTM		12154198
566	N-GlycoSiteAtlas		26571101
566	UniPep
566	UniProtKB		12154198
616	PDB		23780344
616	N-GlycoSiteAtlas		26571101

Family and domain data

Database	Domain/Family name
InterPro	Furin-like_Cys-rich_dom
InterPro	Furin_repeat
InterPro	GF_recep_IV
InterPro	Growth_fac_rcpt_cys_sf
InterPro	Kinase-like_dom_sf
InterPro	Prot_kinase_dom
InterPro	Rcpt_L-dom
InterPro	Rcpt_L-dom_sf
InterPro	Ser-Thr/Tyr_kinase_cat_dom
InterPro	Tyr_kinase_EGF/ERB/XmrK_rcpt
Pfam	Furin-like
Pfam	GF_recep_IV
Pfam	PK_Tyr_Ser-Thr
Pfam	Recep_L_domain

Interactions

With (links to EBI)	#Exp	PubMed links
EGFR_HUMAN	9	24189400 , 23436906 , 22439932 , 10572067
HLAA_HUMAN	3	24189400 , 28514442
LRIG1_HUMAN	2	15282549
PK3CB_HUMAN	2	24189400
EFTU_HUMAN	2	24189400
HS90A_HUMAN	2	24189400
RT27_HUMAN	2	24189400
GRB2_HUMAN	3	24189400 , 24658140
HS90B_HUMAN	3	24189400 , 22939624
GRB7_RAT	3	31585087
BIP_HUMAN	2	24189400
CSK_RAT	3	31585087
HLAB_HUMAN	2	24189400
P85A_HUMAN	23	21075308 , 20227043 , 24189400 , 22439932 , 10572067
SHC1_HUMAN	3	24189400 , 24658140
HDAC6_HUMAN	2	20029029 , 31980649
CDC37_HUMAN	2	24189400
F1LNG5_RAT	2	31585087
RT17_HUMAN	2	24189400
S10AA_HUMAN	2	24189400 , 31980649
P85B_HUMAN	2	24189400
CALX_HUMAN	2	24189400
TBA4A_HUMAN	2	24189400 , 28514442
P55G_HUMAN	2	24189400
ERBB2_HUMAN	21	21075308 , 16843263 , 19411071 , 20227043 , 7592681 , 24557338 , 22806884 , 23436906 , 23688700 , 25241761 , 17426253 , 23680147 , 10572067
PK3CA_HUMAN	3	19411071 , 24189400
NRG1_HUMAN	7	7592681 , unassigned1913 , 28988771
ERBB4_HUMAN	4	20227043 , 10572067

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.