PolarProtDb

Gene name

ENPP3 (PDNP3,LOC100073089)

Experiment(s)

For this entry:

ENPP3_RAT (ENPP3)

Species	Rattus norvegicus
Localization	Apical plasma membrane
Reference	Bello V,Goding JW,Greengrass V,Sali A,Dubljevic V,Lenoir C,Trugnan G,Maurice M (2001) Characterization of a di-leucine-based signal in the cytoplasmic tail of the nucleotide-pyrophosphatase NPP1 that mediates basolateral targeting but not endocytosis., Mol Biol Cell, 12, 3004-15. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Kidney
Cell	MDCK cells (distal tubule)
Notes

For ortholog entries:

ENPP3_HUMAN

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	22	Cytoplasmic
23	43	Membrane
44	875	Extracellular

Phosphorylation

Position	Resource
206	3753305

Glycosylation

Position	Site resource	PubMed link(s)
237	PDB	30022031
237	PDB	30022031
237	PDB	30022031
237	PDB	30022031
237	PDB	30387774
237	PDB	30022031
280	PDB	30022031
280	PDB	30387774
280	PDB	30022031
280	PDB	30022031
280	PDB	30022031
289	PDB	30022031
289	PDB	30022031
289	PDB	30022031
533	PDB	30022031
533	PDB	30387774
533	PDB	30022031
533	PDB	30022031
533	PDB	30022031
533	PDB	30022031
574	PDB	30022031
574	PDB	30022031
574	PDB	30022031
574	PDB	30022031
702	PDB	30022031
702	PDB	30022031
789	PDB	30022031
789	PDB	30022031
789	PDB	30022031
789	PDB	30387774

Family and domain data

Database	Domain/Family name
InterPro	Alkaline_phosphatase_core_sf
InterPro	DNA/RNA_non-sp_Endonuclease
InterPro	Extracellular_endonuc_su_A
InterPro	Phosphodiest/P_Trfase
InterPro	Somatomedin_B-like_dom_sf
InterPro	Somatomedin_B_dom
Pfam	Endonuclease_NS
Pfam	Phosphodiest
Pfam	Somatomedin_B