Gene name

Enpp1 (M6S1,Npps,Pc1,Pdnp1)

Experiment(s)

For this entry:
ENPP1_MOUSE (Enpp1)
Species Mus musculus
Localization Basolateral plasma membrane
Reference Bello V,Goding JW,Greengrass V,Sali A,Dubljevic V,Lenoir C,Trugnan G,Maurice M (2001) Characterization of a di-leucine-based signal in the cytoplasmic tail of the nucleotide-pyrophosphatase NPP1 that mediates basolateral targeting but not endocytosis., Mol Biol Cell, 12, 3004-15.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Kidney
Cell MDCK cells (distal tubule)
Notes A non-canonical dileucine motif was responsible for basolateral sorting
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 58 Cytoplasmic
59 79 Membrane
80 906 Extracellular
Phosphorylation
Position Resource
25 4701736
238 451402
Glycosylation

Family and domain data

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