Gene name
Hsp90b1 (Grp94,Tra1,Tra-1)
Experiment(s)
For this entry:
ENPL_HUMAN (Hsp90b1)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 803 | Extracellular |
Phosphorylation
| Position | Resource |
|---|---|
| 42 | 4701988 |
| 44 | 477983 |
| 64 | 34500401 |
| 92 | 18010141 |
| 94 | 3784047 |
| 106 | 14736064 |
| 109 | 14736061 |
| 127 | 55370700 |
| 133 | 15176973 |
| 165 | 18910699 |
| 169 | 54414221 |
| 171 | 31884456 |
| 172 | 27450093 |
| 179 | 18910690 |
| 187 | 23111453 |
| 200 | 18910693 |
| 201 | 18910696 |
| 225 | 55370705 |
| 227 | 55370710 |
| 256 | 55370715 |
| 258 | 55370720 |
| 280 | 55370725 |
| 288 | 55370730 |
| 306 | 484073 |
| 347 | 3082300 |
| 385 | 31856545 |
| 391 | 27450096 |
| 392 | 31875071 |
| 401 | 38485688 |
| 403 | 31861018 |
| 408 | 3561426 |
| 429 | 4330092 |
| 439 | 31860531 |
| 447 | 31887851 |
| 468 | 18910687 |
| 501 | 27450087 |
| 504 | 27450090 |
| 527 | 55370735 |
| 539 | 38485683 |
| 544 | 22779944 |
| 545 | 22779947 |
| 551 | 54414226 |
| 552 | 15176964 |
| 604 | 56568813 |
| 641 | 55370740 |
| 643 | 55370745 |
| 652 | 463390 |
| 667 | 463391 |
| 669 | 38485693 |
| 674 | 31855603 |
| 675 | 57812706 |
| 677 | 463392 |
| 678 | 472839 |
| 680 | 31857264 |
| 684 | 15176958 |
| 727 | 31864486 |
| 735 | 25294086 |
| 746 | 31859444 |
| 786 | 3180642 |
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | HATPase_C |
| InterPro | HATPase_C_sf |
| InterPro | Heat_shock_protein_90_CS |
| InterPro | HSP90_C |
| InterPro | Hsp90_fam |
| InterPro | Hsp90_N |
| InterPro | Ribosomal_S5_D2-typ_fold |
| Pfam | HATPase_c |
| Pfam | HSP90 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| EGFR_HUMAN | 2 | 20029029 , 31980649 |
| CFTR_HUMAN | 8 | 29924966 |
| LRRK2_HUMAN | 2 | 31046837 |
| TECT3_HUMAN | 2 | 26638075 |
| MATN3_HUMAN | 4 | 23956175 |
| SODC_HUMAN | 4 | 29128334 |
| VDAC1_HUMAN | 2 | 29128334 |
| SNF5_HUMAN | 4 | 30108113 |
| COX15_HUMAN | 3 | 29128334 |
| SDHA_HUMAN | 2 | 29128334 |
| SOAT1_HUMAN | 4 | 29128334 |
| HCD2_HUMAN | 2 | 29128334 |
| TECT1_HUMAN | 2 | 26638075 |
| ODO2_HUMAN | 2 | 29128334 |
| CREL2_MOUSE | 4 | 23956175 |
| GBRL2_HUMAN | 3 | 20562859 |
| COMP_HUMAN | 2 | 23956175 |
| BIP_HUMAN | 2 | 30021884 , 26496610 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.