Gene name
Hsp90b1 (Grp94,Tra1,Tra-1)
Experiment(s)
For this entry:
ENPL_HUMAN (Hsp90b1)
Species | Homo sapiens |
---|---|
Localization | Non polar membrane |
Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
Evidence level | Large-scale proteomics |
Organ | Lung |
Cell | Airway epithel cells |
Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 803 | Extracellular |
Phosphorylation
Position | Resource |
---|---|
42 | 4701988 |
44 | 477983 |
64 | 34500401 |
92 | 18010141 |
94 | 3784047 |
106 | 14736064 |
109 | 14736061 |
127 | 55370700 |
133 | 15176973 |
165 | 18910699 |
169 | 54414221 |
171 | 31884456 |
172 | 27450093 |
179 | 18910690 |
187 | 23111453 |
200 | 18910693 |
201 | 18910696 |
225 | 55370705 |
227 | 55370710 |
256 | 55370715 |
258 | 55370720 |
280 | 55370725 |
288 | 55370730 |
306 | 484073 |
347 | 3082300 |
385 | 31856545 |
391 | 27450096 |
392 | 31875071 |
401 | 38485688 |
403 | 31861018 |
408 | 3561426 |
429 | 4330092 |
439 | 31860531 |
447 | 31887851 |
468 | 18910687 |
501 | 27450087 |
504 | 27450090 |
527 | 55370735 |
539 | 38485683 |
544 | 22779944 |
545 | 22779947 |
551 | 54414226 |
552 | 15176964 |
604 | 56568813 |
641 | 55370740 |
643 | 55370745 |
652 | 463390 |
667 | 463391 |
669 | 38485693 |
674 | 31855603 |
675 | 57812706 |
677 | 463392 |
678 | 472839 |
680 | 31857264 |
684 | 15176958 |
727 | 31864486 |
735 | 25294086 |
746 | 31859444 |
786 | 3180642 |
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | HATPase_C |
InterPro | HATPase_C_sf |
InterPro | Heat_shock_protein_90_CS |
InterPro | HSP90_C |
InterPro | Hsp90_fam |
InterPro | Hsp90_N |
InterPro | Ribosomal_S5_D2-typ_fold |
Pfam | HATPase_c |
Pfam | HSP90 |
Interactions
With (links to EBI) | #Exp | PubMed links |
---|---|---|
EGFR_HUMAN | 2 | 20029029 , 31980649 |
CFTR_HUMAN | 8 | 29924966 |
LRRK2_HUMAN | 2 | 31046837 |
TECT3_HUMAN | 2 | 26638075 |
MATN3_HUMAN | 4 | 23956175 |
SODC_HUMAN | 4 | 29128334 |
VDAC1_HUMAN | 2 | 29128334 |
SNF5_HUMAN | 4 | 30108113 |
COX15_HUMAN | 3 | 29128334 |
SDHA_HUMAN | 2 | 29128334 |
SOAT1_HUMAN | 4 | 29128334 |
HCD2_HUMAN | 2 | 29128334 |
TECT1_HUMAN | 2 | 26638075 |
ODO2_HUMAN | 2 | 29128334 |
CREL2_MOUSE | 4 | 23956175 |
GBRL2_HUMAN | 3 | 20562859 |
COMP_HUMAN | 2 | 23956175 |
BIP_HUMAN | 2 | 30021884 , 26496610 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.