Gene name
SLC1A2 (EAAT2,GLT1)
Experiment(s)
For this entry:
EAA2_HUMAN (SLC1A2)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Cheng C,Glover G,Banker G,Amara SG (2002) A novel sorting motif in the glutamate transporter excitatory amino acid transporter 3 directs its targeting in Madin-Darby canine kidney cells and hippocampal neurons., J Neurosci, 22, 10643-52. [PubMed] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | The source of plasmids is not mentioned but likely human |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 44 | Cytoplasmic |
| 45 | 66 | Membrane |
| 67 | 87 | Extracellular |
| 88 | 108 | Membrane |
| 109 | 119 | Cytoplasmic |
| 120 | 141 | Membrane |
| 142 | 238 | Extracellular |
| 239 | 259 | Membrane |
| 260 | 279 | Cytoplasmic |
| 280 | 301 | Membrane |
| 302 | 317 | Extracellular |
| 318 | 339 | Membrane |
| 340 | 387 | Cytoplasmic |
| 388 | 415 | Membrane |
| 416 | 431 | Extracellular |
| 432 | 459 | Membrane |
| 460 | 574 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 206 | N-GlycoSiteAtlas | ||
| 206 | PolarProtDb | 31844046 | |
| 206 | UniPep | ||
| 216 | N-GlycoSiteAtlas | ||
| 216 | PolarProtDb | 31844046 | |
| 216 | UniPep |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Na-dicarboxylate_symporter |
| InterPro | Na-dicarboxylate_symporter_CS |
| InterPro | Na:dicarbo_symporter_sf |
| Pfam | SDF |