Gene name
Abca7
Experiment(s)
For this entry:
E9Q6G4_MOUSE (Abca7)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Linsel-Nitschke P,Jehle AW,Shan J,Cao G,Bacic D,Lan D,Wang N,Tall AR (2005) Potential role of ABCA7 in cellular lipid efflux to apoA-I., J Lipid Res, 46, 86-92. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 22 | Cytoplasmic |
| 23 | 42 | Membrane |
| 43 | 545 | Extracellular |
| 546 | 567 | Membrane |
| 568 | 587 | Cytoplasmic |
| 588 | 610 | Membrane |
| 611 | 622 | Extracellular |
| 623 | 644 | Membrane |
| 645 | 651 | Cytoplasmic |
| 652 | 673 | Membrane |
| 674 | 681 | Extracellular |
| 682 | 703 | Membrane |
| 704 | 1248 | Cytoplasmic |
| 1249 | 1270 | Membrane |
| 1271 | 1557 | Extracellular |
| 1558 | 1579 | Membrane |
| 1580 | 1595 | Cytoplasmic |
| 1596 | 1611 | Membrane |
| 1612 | 1613 | Extracellular |
| 1614 | 1629 | Membrane |
| 1630 | 1637 | Cytoplasmic |
| 1638 | 1659 | Membrane |
| 1660 | 1668 | Extracellular |
| 1669 | 1691 | Membrane |
| 1692 | 1707 | Cytoplasmic |
| 1708 | 1723 | Membrane |
| 1724 | 1750 | Extracellular |
| 1751 | 1773 | Membrane |
| 1774 | 2167 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | ABCA |
| InterPro | ABCA7 |
| InterPro | P-loop_NTPase |
| Pfam | ABC_tran |