Gene name
Duox1 (THOX1,DUOX,LNOX1)
Experiment(s)
For this entry:
DUOX1_HUMAN (Duox1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
De Deken X,Wang D,Many MC,Costagliola S,Libert F,Vassart G,Dumont JE,Miot F (2000) Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family., J Biol Chem, 275, 23227-33. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Thyroid gland |
| Cell | Follicular cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 22 | Signal peptide |
| 23 | 595 | Extracellular |
| 596 | 616 | Membrane |
| 617 | 1044 | Cytoplasmic |
| 1045 | 1064 | Membrane |
| 1065 | 1087 | Extracellular |
| 1088 | 1105 | Membrane |
| 1106 | 1132 | Cytoplasmic |
| 1133 | 1150 | Membrane |
| 1151 | 1189 | Extracellular |
| 1190 | 1209 | Membrane |
| 1210 | 1222 | Cytoplasmic |
| 1223 | 1243 | Membrane |
| 1244 | 1551 | Extracellular |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | DUOX1/Duox |
| InterPro | DUOX_peroxidase |
| InterPro | EF-hand-dom_pair |
| InterPro | EF_Hand_1_Ca_BS |
| InterPro | EF_hand_dom |
| InterPro | FAD-bd_8 |
| InterPro | FAD-bd_FR_type |
| InterPro | Fe3_Rdtase_TM_dom |
| InterPro | Fe_red_NAD-bd_6 |
| InterPro | FNR_nucleotide-bd |
| InterPro | Haem_peroxidase_animal |
| InterPro | Haem_peroxidase_sf |
| InterPro | Haem_peroxidase_sf_animal |
| InterPro | Riboflavin_synthase-like_b-brl |
| Pfam | An_peroxidase |
| Pfam | EF-hand_1 |
| Pfam | FAD_binding_8 |
| Pfam | Ferric_reduct |
| Pfam | NAD_binding_6 |