Gene name
DRAM2 (TMEM77)
Experiment(s)
For this entry:
DRAM2_MOUSE (DRAM2)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
El-Asrag ME,Sergouniotis PI,McKibbin M,Plagnol V,Sheridan E,Waseem N,Abdelhamed Z,McKeefry D,Van Schil K,Poulter JA,UK Inherited Retinal Disease Consortium.,Johnson CA,Carr IM,Leroy BP,De Baere E,Inglehearn CF,Webster AR,Toomes C,Ali M (2015) Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement., Am J Hum Genet, 96, 948-54. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Photoreceptor cells |
| Notes |
DRAM2_MOUSE (DRAM2)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
El-Asrag ME,Sergouniotis PI,McKibbin M,Plagnol V,Sheridan E,Waseem N,Abdelhamed Z,McKeefry D,Van Schil K,Poulter JA,UK Inherited Retinal Disease Consortium.,Johnson CA,Carr IM,Leroy BP,De Baere E,Inglehearn CF,Webster AR,Toomes C,Ali M (2015) Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement., Am J Hum Genet, 96, 948-54. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Pigment epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 10 | Cytoplasmic |
| 11 | 32 | Membrane |
| 33 | 53 | Extracellular |
| 54 | 73 | Membrane |
| 74 | 93 | Cytoplasmic |
| 94 | 110 | Membrane |
| 111 | 117 | Extracellular |
| 118 | 138 | Membrane |
| 139 | 159 | Cytoplasmic |
| 160 | 180 | Membrane |
| 181 | 205 | Extracellular |
| 206 | 226 | Membrane |
| 227 | 267 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 259 | 54248203 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | DRAM2 |
| InterPro | Frag1/DRAM/Sfk1 |
| Pfam | Frag1 |