PolarProtDb

Gene name

Cubn (Ifcr)

Experiment(s)

For this entry:

CUBN_MOUSE (Cubn)

Species	Mus musculus
Localization	Apical plasma membrane
Reference	Strope S,Rivi R,Metzger T,Manova K,Lacy E (2004) Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules., Development, 131, 4787-95. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Embryonic epithel
Cell	Visceral endoderm cells
Notes	The apical localization of cubilin is dependent on heteromerization with amnionless

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	3623	Extracellular

Phosphorylation

Position	Resource
1016	31907121
1804	25735232
2538	20651192

Glycosylation

Position	Site resource	PubMed link(s)
1217	ACGGD-BD
1217	ACGGD-BD
1217	ACGGD-BD
1217	ACGGD-BD
1217	ACGGD-BD
2085	dbPTM	19349973
2085	UniProtKB	19349973
2925	dbPTM	19349973
2925	UniProtKB	19349973
3125	dbPTM	19349973
3125	UniProtKB	19349973

Family and domain data

Database	Domain/Family name
InterPro	CUB_dom
InterPro	EGF-like_Ca-bd_dom
InterPro	EGF-like_CS
InterPro	EGF-like_dom
InterPro	EGF-type_Asp/Asn_hydroxyl_site
InterPro	EGF_Ca-bd_CS
InterPro	EGF_dom
InterPro	Sperma_CUB_dom_sf
Pfam	CUB
Pfam	EGF
Pfam	EGF_3
Pfam	EGF_CA
Pfam	hEGF