Gene name

Cubn (Ifcr)

Experiment(s)

For this entry:
CUBN_MOUSE (Cubn)
Species Mus musculus
Localization Apical plasma membrane
Reference Strope S,Rivi R,Metzger T,Manova K,Lacy E (2004) Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules., Development, 131, 4787-95.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Embryonic epithel
Cell Visceral endoderm cells
Notes The apical localization of cubilin is dependent on heteromerization with amnionless
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 3623 Extracellular
Phosphorylation
Position Resource
1016 31907121
1804 25735232
2538 20651192
Glycosylation
Position Site resource Glycan resource PubMed link(s)
1217 ACGGD-BD WURCS=2.0/3,10,0+/[axxxxh-1x_1-5_?*][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2-2-2-2-3-3-3-3-3/
1217 ACGGD-BD WURCS=2.0/3,14,0+/[axxxxh-1x_1-5_?*][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-3-3-3-3-3-3/
1217 ACGGD-BD WURCS=2.0/3,11,0+/[axxxxh-1x_1-5_?*][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2-2-2-2-3-3-3-3-3-3/
1217 ACGGD-BD WURCS=2.0/3,12,0+/[axxxxh-1x_1-5_?*][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-3-3-3-3-3/
1217 ACGGD-BD WURCS=2.0/3,11,0+/[axxxxh-1x_1-5_?*][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2-2-2-2-2-3-3-3-3-3/
2085 dbPTM 19349973
2085 UniProtKB 19349973
2925 dbPTM 19349973
2925 UniProtKB 19349973
3125 dbPTM 19349973
3125 UniProtKB 19349973

Family and domain data

Database Domain/Family name
InterPro CUB_dom
InterPro EGF-like_Ca-bd_dom
InterPro EGF-like_CS
InterPro EGF-like_dom
InterPro EGF-type_Asp/Asn_hydroxyl_site
InterPro EGF_Ca-bd_CS
InterPro EGF_dom
InterPro Sperma_CUB_dom_sf
Pfam CUB
Pfam EGF
Pfam EGF_3
Pfam EGF_CA
Pfam hEGF

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