Gene name
CRB2
Experiment(s)
For this entry:
CRUM2_MOUSE (CRB2)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Ramkumar N,Omelchenko T,Silva-Gagliardi NF,McGlade CJ,Wijnholds J,Anderson KV (2016) Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation., Nat Cell Biol, 18, 1281-1291. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Embryonic epithel |
| Cell | Primitive streak cells |
| Notes | Detected in developing mouse embryos |
CRUM2_MOUSE (CRB2)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Alves CH,Sanz AS,Park B,Pellissier LP,Tanimoto N,Beck SC,Huber G,Murtaza M,Richard F,Sridevi Gurubaran I,Garcia Garrido M,Levelt CN,Rashbass P,Le Bivic A,Seeliger MW,Wijnholds J (2013) Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene., Hum Mol Genet, 22, 35-50. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Photoreceptor cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 36 | Signal peptide |
| 37 | 1221 | Extracellular |
| 1222 | 1243 | Membrane |
| 1244 | 1282 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ConA-like_dom_sf |
| InterPro | EGF-like_Ca-bd_dom |
| InterPro | EGF-like_CS |
| InterPro | EGF-like_dom |
| InterPro | EGF-type_Asp/Asn_hydroxyl_site |
| InterPro | EGF_Ca-bd_CS |
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | Laminin_G |
| Pfam | EGF |
| Pfam | hEGF |
| Pfam | Laminin_G_2 |