Gene name
COL17A1 (BP180,BPAG2)
Experiment(s)
For this entry:
COHA1_HUMAN (COL17A1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Chin AR,Yan W,Cao M,Liu X,Wang SE (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia., J Mammary Gland Biol Neoplasia, 23, 165-176. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Mammary gland |
| Cell | MCF10A cells (acinar cells) |
| Notes |
COHA1_HUMAN (COL17A1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Jacków J,Schlosser A,Sormunen R,Nyström A,Sitaru C,Tasanen K,Bruckner-Tuderman L,Franzke CW (2016) Generation of a Functional Non-Shedding Collagen XVII Mouse Model: Relevance of Collagen XVII Shedding in Wound Healing., J Invest Dermatol, 136, 516-525. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Skin |
| Cell | Keratinocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 467 | Extracellular |
| 468 | 489 | Membrane |
| 490 | 523 | Cytoplasmic |
| 524 | 539 | Membrane |
| 540 | 803 | Extracellular |
| 804 | 819 | Membrane |
| 820 | 1381 | Cytoplasmic |
| 1382 | 1397 | Membrane |
| 1398 | 1497 | Extracellular |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 1300 | 1303 | SVRR | TRG_ER_diArg_1 |
Phosphorylation
| Position | Resource |
|---|---|
| 40 | 473120 |
| 45 | 50776190 |
| 56 | 15409115 |
| 61 | 2424944 |
| 62 | 2424943 |
| 64 | 455162 |
| 67 | 34371885 |
| 70 | 15409112 |
| 79 | 15418682 |
| 80 | 15402845 |
| 85 | 472232 |
| 88 | 4715326 |
| 89 | 38494574 |
| 93 | 472233 |
| 96 | 472234 |
| 105 | 34355853 |
| 109 | 23095172 |
| 114 | 23095157 |
| 117 | 27446551 |
| 137 | 38485397 |
| 148 | 480594 |
| 150 | 4715331 |
| 152 | 4945302 |
| 153 | 4945849 |
| 156 | 23095169 |
| 170 | 17551301 |
| 172 | 15402866 |
| 174 | 15402869 |
| 182 | 15402863 |
| 303 | 12477713 |
| 305 | 12477714 |
| 367 | 34551609 |
| 384 | 34349374 |
| 396 | 6158500 |
| 400 | 36250611 |
| 512 | 34351004 |
| 515 | 34351007 |
| 542 | 484006 |
| 544 | 484007 |
| 640 | 36419565 |
| 1124 | 23095154 |
| 1131 | 34350157 |
| 1287 | 23095160 |
| 1296 | 23095162 |
| 1299 | 23095164 |
| 1300 | 23095166 |
| 1395 | 477316 |
Glycosylation
Family and domain data
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CSTFT_HUMAN | 3 | 32296183 |
| WHRN_HUMAN | 3 | 32296183 |
| UBQL2_HUMAN | 3 | 32296183 |
| PLOD3_HUMAN | 3 | 32296183 |
| PNKP_HUMAN | 3 | 32296183 |
| PPIL1_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.