PolarProtDb

Gene name

COL4A1

Experiment(s)

For this entry:

CO4A1_HUMAN (COL4A1)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Kidney
Cell	Proximal tubules
Notes	Inferred from the Tissue Atlas

CO4A1_HUMAN (COL4A1)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Large intestine
Cell	Enterocytes
Notes	Inferred from the Tissue Atlas

CO4A1_HUMAN (COL4A1)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Liver
Cell	Hepatocytes
Notes	Inferred from the Tissue Atlas

CO4A1_HUMAN (COL4A1)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Placenta
Cell	Trophoblast cells
Notes	Inferred from the Tissue Atlas

CO4A1_HUMAN (COL4A1)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Testis
Cell	Sertoli cells
Notes	Inferred from the Tissue Atlas

For ortholog entries:

CO4A1_MOUSE

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	1669	Extracellular

Phosphorylation

Position	Resource
6	23095309
23	23095306
348	465142
892	50776211
1012	25287807
1077	27446565
1226	25287810
1231	25287813

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
126	UniPep
401	O-GlycoProteomDB
1449	O-GlycoProteomDB
1525	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
1532	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171

Family and domain data

Database	Domain/Family name
InterPro	Collagen
InterPro	Collagen_IV_NC
InterPro	Collagen_IV_NC_sf
InterPro	CTDL_fold
Pfam	C4
Pfam	Collagen

Interactions

With (links to EBI)	#Exp	PubMed links
CO4A2_HUMAN	2	12011424

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.