PolarProtDb

Gene name

Cnnm4 (Acdp4,Kiaa1592)

Experiment(s)

For this entry:

CNNM4_MOUSE (Cnnm4)

Species	Mus musculus
Localization	Basolateral plasma membrane
Reference	Yamazaki D,Funato Y,Miura J,Sato S,Toyosawa S,Furutani K,Kurachi Y,Omori Y,Furukawa T,Tsuda T,Kuwabata S,Mizukami S,Kikuchi K,Miki H (2013) Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model., PLoS Genet, 9, e1003983. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Large intestine
Cell	Enterocytes
Notes

CNNM4_MOUSE (Cnnm4)

Species	Mus musculus
Localization	Basolateral plasma membrane
Reference	Yamazaki D,Funato Y,Miura J,Sato S,Toyosawa S,Furutani K,Kurachi Y,Omori Y,Furukawa T,Tsuda T,Kuwabata S,Mizukami S,Kikuchi K,Miki H (2013) Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model., PLoS Genet, 9, e1003983. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Teeth
Cell	Ameloblasts
Notes

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	35	Signal peptide
36	182	Extracellular
183	203	Membrane
204	237	Cytoplasmic
238	258	Membrane
259	261	Extracellular
262	283	Membrane
284	293	Cytoplasmic
294	314	Membrane
315	771	Extracellular

Phosphorylation

Position	Resource
29	25734633
125	18504796
133	18504799
657	5207727
661	4170223
766	4735045

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
119	Glyconnect	$WURCS=2.0/2,9,8/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?$	30899004
119	Glyconnect	$WURCS=2.0/2,5,4/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2/a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?$	30899004
119	Glyconnect	$WURCS=2.0/2,10,9/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?$	30899004
119	Glyconnect	$WURCS=2.0/2,6,5/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?$	30899004
119	Glyconnect	$WURCS=2.0/2,11,10/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?$	30899004

Family and domain data

Database	Domain/Family name
InterPro	CBS_dom
InterPro	cNMP-bd-like
InterPro	CNNM
Pfam	CBS
Pfam	DUF21