Gene name
CNNM2 (Acdp2)
Experiment(s)
For this entry:
CNNM2_HUMAN (CNNM2)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Stuiver M,Lainez S,Will C,Terryn S,Günzel D,Debaix H,Sommer K,Kopplin K,Thumfart J,Kampik NB,Querfeld U,Willnow TE,Němec V,Wagner CA,Hoenderop JG,Devuyst O,Knoers NV,Bindels RJ,Meij IC,Müller D (2011) CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia., Am J Hum Genet, 88, 333-43. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
CNNM2_HUMAN (CNNM2)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Stuiver M,Lainez S,Will C,Terryn S,Günzel D,Debaix H,Sommer K,Kopplin K,Thumfart J,Kampik NB,Querfeld U,Willnow TE,Němec V,Wagner CA,Hoenderop JG,Devuyst O,Knoers NV,Bindels RJ,Meij IC,Müller D (2011) CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia., Am J Hum Genet, 88, 333-43. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Henle's loop / TAL cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 39 | Cytoplasmic |
| 40 | 60 | Membrane |
| 61 | 258 | Extracellular |
| 259 | 279 | Membrane |
| 280 | 313 | Cytoplasmic |
| 314 | 334 | Membrane |
| 335 | 338 | Extracellular |
| 339 | 359 | Membrane |
| 360 | 368 | Cytoplasmic |
| 369 | 389 | Membrane |
| 390 | 875 | Extracellular |
Phosphorylation
Glycosylation
Family and domain data
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| TMM17_HUMAN | 2 | 26638075 |
| TP4A1_HUMAN | 2 | 28330616 |
| TP4A2_HUMAN | 2 | 28330616 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.