PolarProtDb

Gene name

CLCN2 (Clc2)

Experiment(s)

For this entry:

CLCN2_MOUSE (CLCN2)

Species	Mus musculus
Localization	Basolateral plasma membrane
Reference	Peña-Münzenmayer G,Catalán M,Cornejo I,Figueroa CD,Melvin JE,Niemeyer MI,Cid LP,Sepúlveda FV (2005) Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif., J Cell Sci, 118, 4243-52. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Large intestine
Cell	Enterocytes
Notes	Not expressed in crypts

CLCN2_MOUSE (CLCN2)

Species	Mus musculus
Localization	Basolateral plasma membrane
Reference	Peña-Münzenmayer G,Catalán M,Cornejo I,Figueroa CD,Melvin JE,Niemeyer MI,Cid LP,Sepúlveda FV (2005) Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif., J Cell Sci, 118, 4243-52. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Small intestine
Cell	Enterocytes
Notes

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	98	Cytoplasmic
99	115	Membrane
116	142	Extracellular
143	163	Membrane
164	191	Cytoplasmic
192	208	Membrane
209	246	Extracellular
247	269	Membrane
270	285	Cytoplasmic
286	302	Membrane
303	328	Extracellular
329	349	Membrane
350	371	Cytoplasmic
372	391	Membrane
392	438	Extracellular
439	459	Membrane
460	461	Cytoplasmic
462	482	Membrane
483	502	Extracellular
503	519	Membrane
520	521	Cytoplasmic
522	537	Membrane
538	539	Extracellular
540	556	Membrane
557	908	Cytoplasmic

Phosphorylation

Position	Resource
28	15499708
60	27723048
649	50775962
666	27722617
669	29576389
673	27721730
712	3919072
714	8088623
739	27446406
866	27446409
875	1868293551
899	40509949
901	40509953
903	40509957

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
411	Glyconnect	$WURCS=2.0/2,7,6/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?$	30899004

Family and domain data

Database	Domain/Family name
InterPro	CBS_dom
InterPro	Cl-channel-2
InterPro	Cl-channel_core
InterPro	Cl-channel_volt-gated
Pfam	Voltage_CLC