PolarProtDb

Gene name

CEACAM5 (CEA)

Experiment(s)

For this entry:

CEAM5_HUMAN (CEACAM5)

Species	Homo sapiens
Localization	Apical plasma membrane
Reference	Frängsmyr L,Baranov V,Hammarström S (1999) Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat., Tumour Biol, 20, 277-92. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Large intestine
Cell	Enterocytes
Notes

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	34	Signal peptide
35	681	Extracellular
682	701	Membrane
702	702	Cytoplasmic

Phosphorylation

Position	Resource
199	25286888
201	1244130
206	25286890
213	25286892
226	23092592
404	11129101
419	11129104
421	11129107
476	56652484
680	25286886

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
104	N-GlycoSiteAtlas		19658139
115	N-GlycoSiteAtlas		19658139
152	N-GlycoSiteAtlas		23090970
182	N-GlycoSiteAtlas		24495048
182	PolarProtDb		31844046
197	Glyconnect	$WURCS=2.0/2,9,8/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?$	29741879
197	Glyconnect	$WURCS=2.0/2,7,6/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?$	29741879
197	Glyconnect	$WURCS=2.0/2,5,4/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2/a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?$	29741879
197	Glyconnect	$WURCS=2.0/2,8,7/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?$	29741879
197	N-GlycoSiteAtlas		24495048
204	PolarProtDb		31844046
204	N-GlycoSiteAtlas		16740002 , 19196183 , 22457533 , 22106898 , 25247386 , 26256267
208	N-GlycoSiteAtlas		23090970
208	PolarProtDb		31844046
246	dbPTM		19159218
246	N-GlycoSiteAtlas		23090970
246	UniProtKB		19159218
288	N-GlycoSiteAtlas		24495048
292	N-GlycoSiteAtlas		24495048
360	N-GlycoSiteAtlas		24495048
375	N-GlycoSiteAtlas		25247386 , 26256267
375	Glyconnect	$WURCS=2.0/2,5,4/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2/a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?$	29741879
466	N-GlycoSiteAtlas
466	PolarProtDb		31844046
480	N-GlycoSiteAtlas		23090970
508	N-GlycoSiteAtlas		23090970
529	N-GlycoSiteAtlas
553	Glyconnect	$WURCS=2.0/2,5,4/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2/a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?$	29741879
553	N-GlycoSiteAtlas		24495048
553	Glyconnect	$WURCS=2.0/2,8,7/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?$	29741879
553	Glyconnect	$WURCS=2.0/2,7,6/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?$	29741879
553	Glyconnect	$WURCS=2.0/2,9,8/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?$	29741879
560	dbPTM		16740002
560	N-GlycoSiteAtlas		16740002 , 19196183 , 22457533 , 22106898 , 25247386 , 26256267
560	UniProtKB		16740002
580	N-GlycoSiteAtlas		24495048
650	N-GlycoSiteAtlas		23090970
665	N-GlycoSiteAtlas		26256267

Family and domain data

Database	Domain/Family name
InterPro	Ig-like_dom
InterPro	Ig-like_dom_sf
InterPro	Ig-like_fold
InterPro	Ig_sub
InterPro	Ig_sub2
InterPro	Ig_V-set
Pfam	Ig_2
Pfam	V-set

Interactions

With (links to EBI)	#Exp	PubMed links
K0BRG7_MERS	4	27489282
ESR1_HUMAN	2	31527615

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.