Gene name
CD9 (MIC3,TSPAN29)
Experiment(s)
For this entry:
CD9_HUMAN (CD9)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Imhof I,Gasper WJ,Derynck R (2008) Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization., J Cell Sci, 121, 2265-74. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 13 | Cytoplasmic |
| 14 | 35 | Membrane |
| 36 | 57 | Extracellular |
| 58 | 79 | Membrane |
| 80 | 88 | Cytoplasmic |
| 89 | 110 | Membrane |
| 111 | 194 | Extracellular |
| 195 | 217 | Membrane |
| 218 | 228 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | CD9_LEL |
| InterPro | Tetraspanin |
| InterPro | Tetraspanin/Peripherin |
| InterPro | Tetraspanin_CS |
| InterPro | Tetraspanin_EC2_sf |
| Pfam | Tetraspanin |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| IGSF8_HUMAN | 2 | 30833792 , 28514442 |
| ODFP4_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.