Gene name
CD63 (MLA1,TSPAN30)
Experiment(s)
For this entry:
CD63_HUMAN (CD63)
Species | Homo sapiens |
---|---|
Localization | Basolateral plasma membrane |
Reference |
Schulze U,Brast S,Grabner A,Albiker C,Snieder B,Holle S,Schlatter E,Schröter R,Pavenstädt H,Herrmann E,Lambert C,Spoden GA,Florin L,Saftig P,Ciarimboli G (2017) Tetraspanin CD63 controls basolateral sorting of organic cation transporter 2 in renal proximal tubules., FASEB J, 31, 1421-1433. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Kidney |
Cell | Proximal tubules |
Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 11 | Cytoplasmic |
12 | 35 | Membrane |
36 | 51 | Extracellular |
52 | 73 | Membrane |
74 | 82 | Cytoplasmic |
83 | 106 | Membrane |
107 | 204 | Extracellular |
205 | 228 | Membrane |
229 | 238 | Cytoplasmic |
Phosphorylation
Position | Resource |
---|---|
159 | 18909320 |
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | CD63_LEL |
InterPro | Tetraspanin |
InterPro | Tetraspanin/Peripherin |
InterPro | Tetraspanin_CS |
InterPro | Tetraspanin_EC2_sf |
Pfam | Tetraspanin |
Interactions
With (links to EBI) | #Exp | PubMed links |
---|---|---|
TIMP1_HUMAN | 3 | 28030805 |
ENV_HV1H2 | 4 | 25312088 |
TMM80_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.