Gene name
Bace1 (Bace,KIAA1149)
Experiment(s)
For this entry:
BACE1_HUMAN (Bace1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Capell A,Meyn L,Fluhrer R,Teplow DB,Walter J,Haass C (2002) Apical sorting of beta-secretase limits amyloid beta-peptide production., J Biol Chem, 277, 5637-43. [PubMed] [DOI] |
| Evidence level | Other |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | A membrane side-specific biotinylation and purification scheme was followed |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 21 | Signal peptide |
| 22 | 462 | Extracellular |
| 463 | 478 | Membrane |
| 479 | 501 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 47 | dbPTM | 11099506 | |
| 153 | N-GlycoSiteAtlas | 22148984 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Aspartic_peptidase_A1 |
| InterPro | Aspartic_peptidase_AS |
| InterPro | BACE |
| InterPro | BACE1 |
| InterPro | Memapsin-like |
| InterPro | PEPTIDASE_A1 |
| InterPro | Peptidase_aspartic_dom_sf |
| Pfam | Asp |