Gene name
SLC4A1 (AE1,DI,EPB3)
Experiment(s)
For this entry:
B3AT_RAT (SLC4A1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Alper SL,Natale J,Gluck S,Lodish HF,Brown D (1989) Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase., Proc Natl Acad Sci U S A, 86, 5429-33. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Alpha intercalated cells |
| Notes |
B3AT_RAT (SLC4A1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Petrovic S,Barone S,Xu J,Conforti L,Ma L,Kujala M,Kere J,Soleimani M (2004) SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct., Am J Physiol Renal Physiol, 286, F161-9. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Alpha intercalated cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 424 | Cytoplasmic |
| 425 | 440 | Membrane |
| 441 | 456 | Extracellular |
| 457 | 472 | Membrane |
| 473 | 474 | Cytoplasmic |
| 475 | 490 | Membrane |
| 491 | 506 | Extracellular |
| 507 | 522 | Membrane |
| 523 | 540 | Cytoplasmic |
| 541 | 558 | Membrane |
| 559 | 588 | Extracellular |
| 589 | 604 | Membrane |
| 605 | 620 | Cytoplasmic |
| 621 | 636 | Membrane |
| 637 | 678 | Extracellular |
| 679 | 699 | Membrane |
| 700 | 720 | Cytoplasmic |
| 721 | 736 | Membrane |
| 737 | 738 | Extracellular |
| 739 | 754 | Membrane |
| 755 | 776 | Cytoplasmic |
| 777 | 792 | Membrane |
| 793 | 800 | Extracellular |
| 801 | 816 | Membrane |
| 817 | 857 | Cytoplasmic |
| 858 | 876 | Re-entrant loop |
| 877 | 927 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 658 | UniProtKB |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Anion_exchange |
| InterPro | Anion_exchange_1 |
| InterPro | Anion_exchange_CS |
| InterPro | Band3_cytoplasmic_dom |
| InterPro | HCO3_transpt_C |
| InterPro | HCO3_transpt_euk |
| InterPro | PTrfase/Anion_transptr |
| Pfam | Band_3_cyto |
| Pfam | HCO3_cotransp |