Gene name
Slc4a2 (Ae2,EPB3L1,HKB3,MPB3L,B3rp2)
Experiment(s)
For this entry:
B3A2_MOUSE (Slc4a2)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Hatano R,Akiyama K,Tamura A,Hosogi S,Marunaka Y,Caplan MJ,Ueno Y,Tsukita S,Asano S (2015) Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice., Hepatology, 61, 1660-71. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Bile duct cells |
| Notes |
B3A2_MOUSE (Slc4a2)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Paine ML,Snead ML,Wang HJ,Abuladze N,Pushkin A,Liu W,Kao LY,Wall SM,Kim YH,Kurtz I (2008) Role of NBCe1 and AE2 in secretory ameloblasts., J Dent Res, 87, 391-5. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Teeth |
| Cell | Ameloblasts |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 703 | Extracellular |
| 704 | 726 | Membrane |
| 727 | 742 | Cytoplasmic |
| 743 | 770 | Membrane |
| 771 | 789 | Extracellular |
| 790 | 812 | Membrane |
| 813 | 821 | Cytoplasmic |
| 822 | 837 | Membrane |
| 838 | 895 | Extracellular |
| 896 | 914 | Membrane |
| 915 | 929 | Cytoplasmic |
| 930 | 950 | Membrane |
| 951 | 987 | Extracellular |
| 988 | 1006 | Membrane |
| 1007 | 1029 | Cytoplasmic |
| 1030 | 1050 | Membrane |
| 1051 | 1110 | Extracellular |
| 1111 | 1131 | Membrane |
| 1132 | 1158 | Cytoplasmic |
| 1159 | 1177 | Membrane |
| 1178 | 1179 | Extracellular |
| 1180 | 1200 | Membrane |
| 1201 | 1237 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Anion_exchange |
| InterPro | Anion_exchange_2 |
| InterPro | Anion_exchange_CS |
| InterPro | Band3_cytoplasmic_dom |
| InterPro | HCO3_transpt_C |
| InterPro | HCO3_transpt_euk |
| InterPro | PTrfase/Anion_transptr |
| Pfam | Band_3_cyto |
| Pfam | HCO3_cotransp |