Gene name
ATP7B (Pina,WND,PWD,WC1)
Experiment(s)
For this entry:
ATP7B_RAT (ATP7B)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Lalioti V,Peiró R,Pérez-Berlanga M,Tsuchiya Y,Muñoz A,Villalba T,Sanchez C,Sandoval IV (2016) Basolateral sorting and transcytosis define the Cu+-regulated translocation of ATP7B to the bile canaliculus., J Cell Sci, 129, 2190-201. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | CAN 10 cells (hepatocytes) |
| Notes |
ATP7B_RAT (ATP7B)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Nyasae LK,Schell MJ,Hubbard AL (2014) Copper directs ATP7B to the apical domain of hepatic cells via basolateral endosomes., Traffic, 15, 1344-65. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | WIF-B cells (hepatocytes) |
| Notes | Translocated to the apical membrane by a Cu2+ stimulus - otherwise vesicular only |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 646 | Cytoplasmic |
| 647 | 666 | Membrane |
| 667 | 686 | Extracellular |
| 687 | 707 | Membrane |
| 708 | 723 | Cytoplasmic |
| 724 | 745 | Membrane |
| 746 | 753 | Extracellular |
| 754 | 773 | Membrane |
| 774 | 915 | Cytoplasmic |
| 916 | 938 | Membrane |
| 939 | 962 | Extracellular |
| 963 | 983 | Membrane |
| 984 | 1312 | Cytoplasmic |
| 1313 | 1334 | Membrane |
| 1335 | 1341 | Extracellular |
| 1342 | 1359 | Membrane |
| 1360 | 1451 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ATPase_P-typ_cyto_dom_N |
| InterPro | ATPase_P-typ_P_site |
| InterPro | ATPase_P-typ_TM_dom_sf |
| InterPro | ATPase_P-typ_transduc_dom_A_sf |
| InterPro | HAD-like_sf |
| InterPro | Heavy-metal-associated_CS |
| InterPro | HMA_Cu_ion-bd |
| InterPro | HMA_dom |
| InterPro | HMA_dom_sf |
| InterPro | P-typ_ATPase_IB |
| InterPro | P_typ_ATPase |
| Pfam | HMA |