Gene name
ATP2B2 (PMCA2)
Experiment(s)
For this entry:
AT2B2_HUMAN (ATP2B2)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Chicka MC,Strehler EE (2003) Alternative splicing of the first intracellular loop of plasma membrane Ca2+-ATPase isoform 2 alters its membrane targeting., J Biol Chem, 278, 18464-70. [PubMed] [DOI] |
| Evidence level | Antibody staining + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Apical localization is dependent on the alternative segment VKKGDGLQLPAADGAAASNAADSANASLVNG |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 105 | Cytoplasmic |
| 106 | 123 | Membrane |
| 124 | 151 | Extracellular |
| 152 | 170 | Membrane |
| 171 | 399 | Cytoplasmic |
| 400 | 418 | Membrane |
| 419 | 442 | Extracellular |
| 443 | 463 | Membrane |
| 464 | 878 | Cytoplasmic |
| 879 | 899 | Membrane |
| 900 | 909 | Extracellular |
| 910 | 926 | Membrane |
| 927 | 954 | Cytoplasmic |
| 955 | 972 | Membrane |
| 973 | 993 | Extracellular |
| 994 | 1011 | Membrane |
| 1012 | 1030 | Cytoplasmic |
| 1031 | 1047 | Membrane |
| 1048 | 1063 | Extracellular |
| 1064 | 1084 | Membrane |
| 1085 | 1243 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
Phosphorylation
| Position | Resource |
|---|---|
| 5 | 34362651 |
| 18 | 2025917 |
| 184 | 23084890 |
| 346 | 36412100 |
| 449 | 23084899 |
| 469 | 23084908 |
| 470 | 23084893 |
| 498 | 23084896 |
| 528 | 50840205 |
| 597 | 25283812 |
| 604 | 15719191 |
| 726 | 23084902 |
| 792 | 50773891 |
| 794 | 54413403 |
| 798 | 54413407 |
| 818 | 23084905 |
| 822 | 15719194 |
| 940 | 5654909 |
| 1139 | 11422300 |
| 1149 | 4784120 |
| 1150 | 4149173 |
| 1152 | 477547 |
| 1160 | 4784127 |
| 1162 | 4784134 |
| 1178 | 4784145 |
| 1211 | 4784176 |
| 1231 | 2025933 |
| 1234 | 486058 |
| 1238 | 2025937 |
| 1241 | 486059 |
| 1242 | 3194018 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ATP2B2 |
| InterPro | ATP_Ca_trans_C |
| InterPro | ATPase_P-typ_cation-transptr_C |
| InterPro | ATPase_P-typ_cation-transptr_N |
| InterPro | ATPase_P-typ_cyto_dom_N |
| InterPro | ATPase_P-typ_P_site |
| InterPro | ATPase_P-typ_TM_dom_sf |
| InterPro | ATPase_P-typ_transduc_dom_A_sf |
| InterPro | HAD-like_sf |
| InterPro | HAD_sf |
| InterPro | P-type_ATPase_IIB |
| InterPro | P_typ_ATPase |
| Pfam | ATP_Ca_trans_C |
| Pfam | Cation_ATPase_C |
| Pfam | Cation_ATPase_N |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| SCRIB_HUMAN | 2 | 30126976 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.