Gene name
Atp1b1 (ATP1B,Atp4b)
Experiment(s)
For this entry:
AT1B1_HUMAN (Atp1b1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Lobato-Álvarez JA,Roldán ML,López-Murillo TD,González-Ramírez R,Bonilla-Delgado J,Shoshani L (2016) The Apical Localization of Na<sup>+</sup>, K<sup>+</sup>-ATPase in Cultured Human Retinal Pigment Epithelial Cells Depends on Expression of the β<sub>2</sub> Subunit., Front Physiol, 7, 450. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | ARPE-19 cells (pigment epithel cells) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 32 | Cytoplasmic |
| 33 | 53 | Membrane |
| 54 | 303 | Extracellular |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 67 | O-GlycoProteomDB | ||
| 158 | Glyconnect |
|
29741879 |
| 158 | UniProtKB | 12754519 , 19159218 | |
| 158 | UniPep | ||
| 158 | N-GlycoSiteAtlas | 24495048 | |
| 158 | dbPTM | 12754519 , 19159218 | |
| 158 | Glyconnect |
|
29741879 |
| 158 | Glyconnect |
|
|
| 158 | Glyconnect |
|
29741879 |
| 158 | PolarProtDb |
|
29741879 |
| 158 | Glyconnect |
|
29741879 |
| 158 | Glyconnect |
|
29741879 |
| 158 | Glyconnect |
|
29741879 |
| 193 | UniPep | ||
| 193 | UniProtKB | 12754519 , 19159218 | |
| 193 | Glyconnect |
|
29741879 |
| 193 | N-GlycoSiteAtlas | 24495048 | |
| 193 | dbPTM | 12754519 , 19159218 | |
| 193 | Glyconnect |
|
29741879 |
| 193 | Glyconnect |
|
29741879 |
| 193 | Glyconnect |
|
29741879 |
| 193 | Glyconnect |
|
29741879 |
| 193 | Glyconnect |
|
29741879 |
| 193 | Glyconnect |
|
29741879 |
| 193 | Glyconnect |
|
29741879 |
| 193 | Glyconnect |
|
29741879 |
| 193 | Glyconnect |
|
29741879 |
| 265 | Glyconnect |
|
29741879 |
| 265 | Glyconnect |
|
29741879 |
| 265 | Glyconnect |
|
29741879 |
| 265 | Glyconnect |
|
29741879 |
| 265 | Glyconnect |
|
29741879 |
| 265 | dbPTM | 12754519 , 19159218 , 19349973 | |
| 265 | N-GlycoSiteAtlas | 24495048 | |
| 265 | PolarProtDb | 31844046 | |
| 265 | UniPep | ||
| 265 | UniProtKB | 12754519 , 19159218 , 19349973 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Na/K_ATPase_sub_beta |
| InterPro | Na/K_ATPase_sub_beta_chordates |
| InterPro | Na/K_ATPase_sub_beta_sf |
| Pfam | Na_K-ATPase |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| AT1A1_HUMAN | 2 | 30021884 , 25012180 |
| KIRR3_HUMAN | 4 | 25902260 |
| ESR1_HUMAN | 2 | 31527615 |
| P2RY6_HUMAN | 3 | 30833792 |
| B3AT_HUMAN | 8 | 25012180 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.