Gene name
AQP5
Experiment(s)
For this entry:
AQP5_MOUSE (AQP5)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Pani B,Liu X,Bollimuntha S,Cheng KT,Niesman IR,Zheng C,Achen VR,Patel HH,Ambudkar IS,Singh BB (2013) Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1., J Cell Sci, 126, 667-75. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Salivary gland |
| Cell | Acinar cells |
| Notes | Cytoplasmic-to-apical translocation is stimulus-dependent |
AQP5_MOUSE (AQP5)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Inoue R,Sohara E,Rai T,Satoh T,Yokozeki H,Sasaki S,Uchida S (2013) Immunolocalization and translocation of aquaporin-5 water channel in sweat glands., J Dermatol Sci, 70, 26-33. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Sweat glands |
| Cell | Secretory cells |
| Notes | Apical localization in sweat glands appears to be stimulus-dependent |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 13 | Cytoplasmic |
| 14 | 31 | Membrane |
| 32 | 43 | Extracellular |
| 44 | 61 | Membrane |
| 62 | 64 | Cytoplasmic |
| 65 | 78 | Re-entrant loop |
| 79 | 87 | Cytoplasmic |
| 88 | 105 | Membrane |
| 106 | 131 | Extracellular |
| 132 | 149 | Membrane |
| 150 | 159 | Cytoplasmic |
| 160 | 177 | Membrane |
| 178 | 180 | Extracellular |
| 181 | 194 | Re-entrant loop |
| 195 | 203 | Extracellular |
| 204 | 221 | Membrane |
| 222 | 265 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 259 | 460666 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Aquaporin-like |
| InterPro | Aquaporin_5 |
| InterPro | Aquaporin_transptr |
| InterPro | MIP |
| InterPro | MIP_CS |
| Pfam | MIP |