Gene name
AQP2 (cph)
Experiment(s)
For this entry:
AQP2_MOUSE (AQP2)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Estévez R,Boettger T,Stein V,Birkenhäger R,Otto E,Hildebrandt F,Jentsch TJ (2001) Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion., Nature, 414, 558-61. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Collecting ducts |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 12 | Cytoplasmic |
| 13 | 30 | Membrane |
| 31 | 42 | Extracellular |
| 43 | 60 | Membrane |
| 61 | 63 | Cytoplasmic |
| 64 | 77 | Re-entrant loop |
| 78 | 86 | Cytoplasmic |
| 87 | 104 | Membrane |
| 105 | 130 | Extracellular |
| 131 | 148 | Membrane |
| 149 | 158 | Cytoplasmic |
| 159 | 176 | Membrane |
| 177 | 179 | Extracellular |
| 180 | 193 | Re-entrant loop |
| 194 | 201 | Extracellular |
| 202 | 219 | Membrane |
| 220 | 271 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Aquaporin-like |
| InterPro | Aquaporin_transptr |
| InterPro | MIP |
| InterPro | MIP_CS |
| Pfam | MIP |