Gene name
AQP1 (Chip28)
Experiment(s)
For this entry:
AQP1_HUMAN (AQP1)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Motohashi H,Nakao Y,Masuda S,Katsura T,Kamba T,Ogawa O,Inui K (2013) Precise comparison of protein localization among OCT, OAT, and MATE in human kidney., J Pharm Sci, 102, 3302-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 13 | Cytoplasmic |
| 14 | 31 | Membrane |
| 32 | 50 | Extracellular |
| 51 | 68 | Membrane |
| 69 | 71 | Cytoplasmic |
| 72 | 85 | Re-entrant loop |
| 86 | 94 | Cytoplasmic |
| 95 | 112 | Membrane |
| 113 | 138 | Extracellular |
| 139 | 156 | Membrane |
| 157 | 166 | Cytoplasmic |
| 167 | 184 | Membrane |
| 185 | 188 | Extracellular |
| 189 | 202 | Re-entrant loop |
| 203 | 209 | Extracellular |
| 210 | 227 | Membrane |
| 228 | 269 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 42 | N-GlycoSiteAtlas | 24741114 | |
| 42 | PolarProtDb | 31844046 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Aquaporin-like |
| InterPro | Aquaporin_1 |
| InterPro | Aquaporin_transptr |
| InterPro | MIP |
| InterPro | MIP_CS |
| Pfam | MIP |
Interactions
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.