PolarProtDb

Gene name

ADAM9 (Kiaa0021,MCMP,Mdc9,Mltng)

Experiment(s)

For this entry:

ADAM9_MOUSE (ADAM9)

Species	Mus musculus
Localization	Apical plasma membrane
Reference	Parry DA,Toomes C,Bida L,Danciger M,Towns KV,McKibbin M,Jacobson SG,Logan CV,Ali M,Bond J,Chance R,Swendeman S,Daniele LL,Springell K,Adams M,Johnson CA,Booth AP,Jafri H,Rashid Y,Banin E,Strom TM,Farber DB,Sharon D,Blobel CP,Pugh EN Jr,Pierce EA,Inglehearn CF (2009) Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice., Am J Hum Genet, 84, 683-91. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Retina
Cell	Pigment epithel cells
Notes

For ortholog entries:

ADAM9_HUMAN

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	30	Signal peptide
31	697	Extracellular
698	718	Membrane
719	845	Cytoplasmic

Phosphorylation

Position	Resource
825	3965415
841	454619

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
381	Glyconnect	$WURCS=2.0/2,7,6/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?$	30899004
381	Glyconnect	$WURCS=2.0/2,5,4/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2/a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?$	30899004
381	Glyconnect	$WURCS=2.0/2,8,7/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?$	30899004
381	Glyconnect	$WURCS=2.0/2,6,5/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?$	30899004

Family and domain data

Database	Domain/Family name
InterPro	ADAM_Cys-rich
InterPro	Disintegrin_CS
InterPro	Disintegrin_dom
InterPro	Disintegrin_dom_sf
InterPro	EGF-like_dom
InterPro	MetalloPept_cat_dom_sf
InterPro	Peptidase_M12B
InterPro	Peptidase_M12B_N
InterPro	Reprolysin_adamalysin
Pfam	ADAM_CR
Pfam	Disintegrin
Pfam	Pep_M12B_propep
Pfam	Reprolysin

Interactions

With (links to EBI)	#Exp	PubMed links
SYGP1_MOUSE	2	28706196 , 28671696

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.