Gene name
ABCG5
Experiment(s)
For this entry:
ABCG5_MOUSE (ABCG5)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Graf GA,Yu L,Li WP,Gerard R,Tuma PL,Cohen JC,Hobbs HH (2003) ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion., J Biol Chem, 278, 48275-82. [PubMed] [DOI] |
| Evidence level | Other |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes | Co-expression with ABCG8 is needed for apical membrane expression of the latter |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 384 | Cytoplasmic |
| 385 | 404 | Membrane |
| 405 | 422 | Extracellular |
| 423 | 442 | Membrane |
| 443 | 469 | Cytoplasmic |
| 470 | 491 | Membrane |
| 492 | 497 | Extracellular |
| 498 | 522 | Membrane |
| 523 | 528 | Cytoplasmic |
| 529 | 547 | Membrane |
| 548 | 558 | Extracellular |
| 559 | 576 | Re-entrant loop |
| 577 | 620 | Extracellular |
| 621 | 639 | Membrane |
| 640 | 652 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC_2_trans |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | P-loop_NTPase |
| Pfam | ABC2_membrane |
| Pfam | ABC_tran |