Gene name
ABCG1 (ABC8,WHT1)
Experiment(s)
For this entry:
ABCG1_HUMAN (ABCG1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Aye IL,Waddell BJ,Mark PJ,Keelan JA (2010) Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity., Biochim Biophys Acta, 1801, 1013-24. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 420 | Cytoplasmic |
| 421 | 440 | Membrane |
| 441 | 456 | Extracellular |
| 457 | 476 | Membrane |
| 477 | 503 | Cytoplasmic |
| 504 | 525 | Membrane |
| 526 | 531 | Extracellular |
| 532 | 555 | Membrane |
| 556 | 561 | Cytoplasmic |
| 562 | 580 | Membrane |
| 581 | 591 | Extracellular |
| 592 | 609 | Re-entrant loop |
| 610 | 647 | Extracellular |
| 648 | 666 | Membrane |
| 667 | 678 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC_2_trans |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | P-loop_NTPase |
| InterPro | Pigment_permease/Abcg |
| Pfam | ABC2_membrane |
| Pfam | ABC_tran |