PolarProtDb

Gene name

ABCA1 (ABC1,CERP)

Experiment(s)

For this entry:

ABCA1_HUMAN (ABCA1)

Species	Homo sapiens
Localization	Apical plasma membrane
Reference	Aye IL,Waddell BJ,Mark PJ,Keelan JA (2010) Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity., Biochim Biophys Acta, 1801, 1013-24. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Placenta
Cell	Trophoblast cells
Notes

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	22	Cytoplasmic
23	42	Membrane
43	638	Extracellular
639	660	Membrane
661	681	Cytoplasmic
682	703	Membrane
704	715	Extracellular
716	737	Membrane
738	744	Cytoplasmic
745	766	Membrane
767	820	Extracellular
821	842	Membrane
843	1345	Cytoplasmic
1346	1367	Membrane
1368	1654	Extracellular
1655	1676	Membrane
1677	1702	Cytoplasmic
1703	1724	Membrane
1725	1734	Extracellular
1735	1756	Membrane
1757	1766	Cytoplasmic
1767	1788	Membrane
1789	1848	Extracellular
1849	1870	Membrane
1871	2261	Cytoplasmic

Eukaryotic Linear Motif (ELM)

Start	End	Sequence	Motif
1268	1272	ARRNR	TRG_ER_diArg_1
1894	1897	DVRR	TRG_ER_diArg_1

Phosphorylation

Position	Resource
116	56651852
231	54208805
325	29651532
884	27442773
1031	34426230
1042	455499
1145	4706925
1206	3718336
1242	452017
1243	452018
1255	452019
1262	34499001
1296	467381
1536	11079836
1540	11079840
1548	54471400
1582	56568013
1586	56568017
2054	455498
2101	23078124
2234	17550591

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
98	UniProtKB		19159218
98	N-GlycoSiteAtlas		19159218 , 22148984 , 24741114 , 24190977 , 24495048
98	dbPTM		19159218
151	N-GlycoSiteAtlas		24495048
161	N-GlycoSiteAtlas		24495048
196	N-GlycoSiteAtlas
244	dbPTM		19159218
244	N-GlycoSiteAtlas		19159218
244	PolarProtDb		31844046
244	UniProtKB		19159218
349	N-GlycoSiteAtlas		22148984
478	N-GlycoSiteAtlas		24495048
478	PolarProtDb		31844046
489	N-GlycoSiteAtlas		24324730 , 24190977 , 25247386 , 25207853 , 25207853 , 24495048 , 26256267 , 25902405
489	PolarProtDb		31844046
521	N-GlycoSiteAtlas		24495048
1504	N-GlycoSiteAtlas		24495048
1637	N-GlycoSiteAtlas
1637	Glyconnect	$WURCS=2.0/2,11,10/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?$	29741879

Family and domain data

Database	Domain/Family name
InterPro	AAA+_ATPase
InterPro	ABC_transporter-like
InterPro	ABC_transporter_CS
InterPro	ABCA
InterPro	P-loop_NTPase
Pfam	ABC_tran

Interactions

With (links to EBI)	#Exp	PubMed links
SNTB1_HUMAN	3	16192269
SNTA1_HUMAN	2	16192269
APOA1_HUMAN	6	30458687

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.