Gene name
CD109
Experiment(s)
For this entry:
A0A5F4D8V4_CANLF (CD109)
| Species | Canis lupus familiaris |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Caceres PS,Gravotta D,Zager PJ,Dephoure N,Rodriguez-Boulan E (2019) Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins., Proc Natl Acad Sci U S A, 116, 11796-11805. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Cutoff: at least 80% apical |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 136 | Cytoplasmic |
| 137 | 154 | Membrane |
| 155 | 1555 | Extracellular |
| 1556 | 1573 | Membrane |
| 1574 | 1577 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 112 | 115 | TPRR | TRG_ER_diArg_1 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | A-macroglobulin_rcpt-bd |
| InterPro | A-macroglobulin_rcpt-bd_sf |
| InterPro | A2M_N_BRD |
| InterPro | A2M_TED |
| InterPro | Alpha-macroglobulin_TED |
| InterPro | Ig-like_fold |
| InterPro | Ig_E-set |
| InterPro | Macroglobln_a2 |
| InterPro | MacrogloblnA2_CS |
| InterPro | MG2 |
| InterPro | MG3 |
| InterPro | Terpenoid_cyclase/PrenylTrfase |
| Pfam | A2M |
| Pfam | A2M_BRD |
| Pfam | A2M_recep |
| Pfam | MG2 |
| Pfam | MG3 |
| Pfam | TED_complement |