Gene name

CELSR2 (CDHF10,EGFL2,KIAA0279,MEGF3)

Experiment(s)

For this entry:
A0A5F4D6S3_CANLF (CELSR2)
Species Canis lupus familiaris
Localization Basolateral plasma membrane
Reference Caceres PS,Gravotta D,Zager PJ,Dephoure N,Rodriguez-Boulan E (2019) Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins., Proc Natl Acad Sci U S A, 116, 11796-11805.
[PubMed] [DOI]
Evidence level Large-scale proteomics
Organ Kidney
Cell MDCK cells (distal tubule)
Notes
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 35 Signal peptide
36 2381 Extracellular
2382 2404 Membrane
2405 2416 Cytoplasmic
2417 2433 Membrane
2434 2440 Extracellular
2441 2462 Membrane
2463 2483 Cytoplasmic
2484 2503 Membrane
2504 2521 Extracellular
2522 2543 Membrane
2544 2566 Cytoplasmic
2567 2586 Membrane
2587 2593 Extracellular
2594 2615 Membrane
2616 2926 Cytoplasmic

Family and domain data

Database Domain/Family name
InterPro Cadherin-like_dom
InterPro Cadherin-like_sf
InterPro Cadherin_CS
InterPro ConA-like_dom_sf
InterPro EGF-like_Ca-bd_dom
InterPro EGF-like_CS
InterPro EGF-like_dom
InterPro EGF-type_Asp/Asn_hydroxyl_site
InterPro GAIN_dom_N
InterPro GPCR_2-like
InterPro GPCR_2_extracell_dom_sf
InterPro GPCR_2_extracellular_dom
InterPro GPCR_2_secretin-like
InterPro GPS
InterPro Growth_fac_rcpt_cys_sf
InterPro Laminin_EGF
InterPro Laminin_G
Pfam 7tm_2
Pfam Cadherin
Pfam EGF
Pfam GAIN
Pfam GPS
Pfam hEGF
Pfam Laminin_EGF
Pfam Laminin_G_2

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