Gene name
CELSR2 (CDHF10,EGFL2,KIAA0279,MEGF3)
Experiment(s)
For this entry:
A0A5F4D6S3_CANLF (CELSR2)
| Species | Canis lupus familiaris |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Caceres PS,Gravotta D,Zager PJ,Dephoure N,Rodriguez-Boulan E (2019) Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins., Proc Natl Acad Sci U S A, 116, 11796-11805. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 35 | Signal peptide |
| 36 | 2381 | Extracellular |
| 2382 | 2404 | Membrane |
| 2405 | 2416 | Cytoplasmic |
| 2417 | 2433 | Membrane |
| 2434 | 2440 | Extracellular |
| 2441 | 2462 | Membrane |
| 2463 | 2483 | Cytoplasmic |
| 2484 | 2503 | Membrane |
| 2504 | 2521 | Extracellular |
| 2522 | 2543 | Membrane |
| 2544 | 2566 | Cytoplasmic |
| 2567 | 2586 | Membrane |
| 2587 | 2593 | Extracellular |
| 2594 | 2615 | Membrane |
| 2616 | 2926 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Cadherin-like_dom |
| InterPro | Cadherin-like_sf |
| InterPro | Cadherin_CS |
| InterPro | ConA-like_dom_sf |
| InterPro | EGF-like_Ca-bd_dom |
| InterPro | EGF-like_CS |
| InterPro | EGF-like_dom |
| InterPro | EGF-type_Asp/Asn_hydroxyl_site |
| InterPro | GAIN_dom_N |
| InterPro | GPCR_2-like |
| InterPro | GPCR_2_extracell_dom_sf |
| InterPro | GPCR_2_extracellular_dom |
| InterPro | GPCR_2_secretin-like |
| InterPro | GPS |
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | Laminin_EGF |
| InterPro | Laminin_G |
| Pfam | 7tm_2 |
| Pfam | Cadherin |
| Pfam | EGF |
| Pfam | GAIN |
| Pfam | GPS |
| Pfam | hEGF |
| Pfam | Laminin_EGF |
| Pfam | Laminin_G_2 |