Gene name
NT5E (Nt5,Nte)
Experiment(s)
For this entry:
5NTD_HUMAN (NT5E)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Wojtal KA,de Vries E,Hoekstra D,van Ijzendoorn SC (2006) Efficient trafficking of MDR1/P-glycoprotein to apical canalicular plasma membranes in HepG2 cells requires PKA-RIIalpha anchoring and glucosylceramide., Mol Biol Cell, 17, 3638-50. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | HEPG2 cells (hepatocytes) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 26 | Signal peptide |
| 27 | 552 | Extracellular |
| 553 | 573 | Membrane |
| 574 | 574 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 53 | PolarProtDb | 31844046 | |
| 53 | N-GlycoSiteAtlas | 21621025 , 24164404 , 25244057 , 24495048 | |
| 311 | PDB |
![WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/](data:image/png;base64,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)
|
31116985 |
| 311 | UniProtKB | 19159218 , 23142347 | |
| 311 | UniPep | ||
| 311 | PolarProtDb | 31844046 | |
| 311 | N-GlycoSiteAtlas | 19159218 | |
| 311 | dbPTM | 19159218 , 23142347 | |
| 311 | PDB |
|
22997138 |
| 333 | dbPTM | 19159218 , 19349973 | |
| 333 | N-GlycoSiteAtlas | ||
| 333 | PolarProtDb | 31844046 | |
| 333 | UniPep | ||
| 333 | UniProtKB | 19159218 , 19349973 | |
| 403 | dbPTM | 19159218 | |
| 403 | N-GlycoSiteAtlas | 24495048 | |
| 403 | UniProtKB | 19159218 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | 5'-Nucleotdase_C |
| InterPro | 5'-Nucleotdase_C_sf |
| InterPro | 5'-Nucleotdase_CS |
| InterPro | 5_nucleotidase/apyrase |
| InterPro | Calcineurin-like_PHP_ApaH |
| InterPro | Metallo-depent_PP-like |
| Pfam | 5_nucleotid_C |
| Pfam | Metallophos |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CFTR_HUMAN | 8 | 29924966 |
| RNF24_HUMAN | 3 | 32296183 |
| ESR1_HUMAN | 2 | 31527615 |
| ZNRF4_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.