Gene name

SLCO4C1 (OATP4C1,SLC21A20,OATPX)

Experiment(s)

For this entry:
SO4C1_HUMAN (SLCO4C1)
Species Homo sapiens
Localization Basolateral plasma membrane
Reference Toyohara T,Suzuki T,Morimoto R,Akiyama Y,Souma T,Shiwaku HO,Takeuchi Y,Mishima E,Abe M,Tanemoto M,Masuda S,Kawano H,Maemura K,Nakayama M,Sato H,Mikkaichi T,Yamaguchi H,Fukui S,Fukumoto Y,Shimokawa H,Inui K,Terasaki T,Goto J,Ito S,Hishinuma T,Rubera I,Tauc M,Fujii-Kuriyama Y,Yabuuchi H,Moriyama Y,Soga T,Abe T (2009) SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation., J Am Soc Nephrol, 20, 2546-55.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Kidney
Cell Proximal tubules
Notes In the transgenic rat harboring human SLCO4C1
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 105 Cytoplasmic
106 126 Membrane
127 142 Extracellular
143 165 Membrane
166 173 Cytoplasmic
174 195 Membrane
196 228 Extracellular
229 250 Membrane
251 266 Cytoplasmic
267 289 Membrane
290 312 Extracellular
313 334 Membrane
335 381 Cytoplasmic
382 403 Membrane
404 419 Extracellular
420 443 Membrane
444 455 Cytoplasmic
456 474 Membrane
475 578 Extracellular
579 602 Membrane
603 614 Cytoplasmic
615 638 Membrane
639 666 Extracellular
667 690 Membrane
691 724 Cytoplasmic
Phosphorylation
Glycosylation

Family and domain data

Database Domain/Family name
InterPro Kazal_dom
InterPro Kazal_dom_sf
InterPro MFS_dom
InterPro MFS_trans_sf
InterPro OATP
Pfam Kazal_2
Pfam OATP

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