Gene name
SLC11A2 (Dct1,Dmt1,Nramp2)
Experiment(s)
For this entry:
NRAM2_HUMAN (SLC11A2)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Núñez MT,Tapia V,Rojas A,Aguirre P,Gómez F,Nualart F (2010) Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1., Am J Physiol Cell Physiol, 298, C477-85. [PubMed] [DOI] |
| Evidence level | Other |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes | A membrane side-specific biotinylation and purification scheme was followed |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 69 | Cytoplasmic |
| 70 | 85 | Membrane |
| 86 | 101 | Extracellular |
| 102 | 123 | Membrane |
| 124 | 146 | Cytoplasmic |
| 147 | 168 | Membrane |
| 169 | 178 | Extracellular |
| 179 | 199 | Membrane |
| 200 | 208 | Cytoplasmic |
| 209 | 229 | Membrane |
| 230 | 252 | Extracellular |
| 253 | 271 | Membrane |
| 272 | 295 | Cytoplasmic |
| 296 | 317 | Membrane |
| 318 | 368 | Extracellular |
| 369 | 389 | Membrane |
| 390 | 412 | Cytoplasmic |
| 413 | 430 | Membrane |
| 431 | 440 | Extracellular |
| 441 | 461 | Membrane |
| 462 | 475 | Cytoplasmic |
| 476 | 496 | Membrane |
| 497 | 505 | Extracellular |
| 506 | 527 | Membrane |
| 528 | 568 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 336 | N-GlycoSiteAtlas | 26571101 | |
| 336 | PolarProtDb | 31844046 | |
| 349 | N-GlycoSiteAtlas | 24191733 | |
| 349 | PolarProtDb | 31844046 |