Gene name

COL4A1

Experiment(s)

For this entry:
CO4A1_HUMAN (COL4A1)
Species Homo sapiens
Localization Basolateral plasma membrane
Reference Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Kidney
Cell Proximal tubules
Notes Inferred from the Tissue Atlas
CO4A1_HUMAN (COL4A1)
Species Homo sapiens
Localization Basolateral plasma membrane
Reference Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Large intestine
Cell Enterocytes
Notes Inferred from the Tissue Atlas
CO4A1_HUMAN (COL4A1)
Species Homo sapiens
Localization Basolateral plasma membrane
Reference Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Liver
Cell Hepatocytes
Notes Inferred from the Tissue Atlas
CO4A1_HUMAN (COL4A1)
Species Homo sapiens
Localization Basolateral plasma membrane
Reference Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Placenta
Cell Trophoblast cells
Notes Inferred from the Tissue Atlas
CO4A1_HUMAN (COL4A1)
Species Homo sapiens
Localization Basolateral plasma membrane
Reference Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Testis
Cell Sertoli cells
Notes Inferred from the Tissue Atlas
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 1669 Extracellular
Phosphorylation
Glycosylation
Position Site resource Glycan resource PubMed link(s)
126 UniPep
401 O-GlycoProteomDB
1449 O-GlycoProteomDB
1525 UniCarbKB WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30459171
1532 UniCarbKB WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30459171

Family and domain data

Database Domain/Family name
InterPro Collagen
InterPro Collagen_IV_NC
InterPro Collagen_IV_NC_sf
InterPro CTDL_fold
Pfam C4
Pfam Collagen

Interactions

With (links to EBI) #Exp PubMed links
CO4A2_HUMAN 2 12011424
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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