AMPN_PIGSus scrofaApical plasma membrane8375500Functional assayA proteolytic activity assay was utilizedE9Q6G4_MOUSEMus musculusApical plasma membrane15520449Antibody stainingMDR1_HUMANHomo sapiensApical plasma membrane11724763Antibody stainingFunctional transport assays were also used for validationMDR1_HUMANHomo sapiensApical plasma membrane16723498Antibody stainingLocalization was dependent on the proper AKAP proteins and glycolipidsMDR1_HUMANHomo sapiensBasolateral plasma membrane11724763Antibody stainingFunctional transport assays were also used for validationMDR1_RATRattus norvegicusApical plasma membrane10097135Antibody stainingMDR1_RATRattus norvegicusApical plasma membrane18619525Antibody stainingMDR1_RATRattus norvegicusApical plasma membrane18687783Antibody stainingABCBB_MOUSEMus musculusApical plasma membrane24643070Functional assayA functional transporte assay was usedMDR3_HUMANHomo sapiensApical plasma membrane8898203Antibody stainingMRP1_RATRattus norvegicusBasolateral plasma membrane10097135Antibody stainingMRP1_RATRattus norvegicusBasolateral plasma membrane22454528Antibody stainingA MYC tag was used for labellingMRP1_RATRattus norvegicusBasolateral plasma membrane18619525Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane16723498Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane22454528Antibody staining + sub-protein manipulationA dileucine-type apical targeting signal was identified: SQDALV (likely phosphorylated)MRP2_RATRattus norvegicusApical plasma membrane11093774Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane11850532Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane11850532Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane11850532Antibody stainingMRP3_RATRattus norvegicusApical plasma membrane10362653Antibody stainingThis data conflicts with later studiesB8K1W7_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsE9Q467_MOUSEMus musculusBasolateral plasma membrane18687783Antibody stainingQ6QMG6_RATRattus norvegicusBasolateral plasma membrane18619525Antibody stainingMRP6_HUMANHomo sapiensBasolateral plasma membrane12901863Large-scale proteomicsABCG2_HUMANHomo sapiensApical plasma membrane12958161Functional assayA substrate transporter assay was usedABCG2_PIGSus scrofaApical plasma membrane19506252Antibody stainingABCG2_RATRattus norvegicusApical plasma membrane18619525Antibody stainingABCG5_MOUSEMus musculusApical plasma membrane14504269OtherCo-expression with ABCG8 is needed for apical membrane expression of the latterABCG8_MOUSEMus musculusApical plasma membrane14504269Antibody stainingACE2_HUMANHomo sapiensApical plasma membrane16690935Antibody stainingACE2_HUMANHomo sapiensApical plasma membrane32577664Antibody stainingJ9P7Y2_CANLFCanis lupus familiarisApical plasma membrane32531288Large-scale proteomicsM1VKS2_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsF1PFZ9_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsADAM9_HUMANHomo sapiensApical plasma membrane14997207Antibody stainingADAM9_MOUSEMus musculusApical plasma membrane19409519Antibody stainingAGRG2_MOUSEMus musculusApical plasma membrane12420295Antibody stainingAGRG2_HUMANHomo sapiensApical plasma membrane12420295Antibody stainingAA2BR_MOUSEMus musculusApical plasma membrane30746715Antibody stainingRAGE_HUMANHomo sapiensBasolateral plasma membrane15009093Antibody stainingRAGE_HUMANHomo sapiensBasolateral plasma membrane17277156Antibody stainingDetecting endogenous proteinsRAGE_RATRattus norvegicusBasolateral plasma membrane15009093Antibody stainingElectron micrographs were used to clarify localizationAGR2_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredAGRIN_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsF8VPQ6_MOUSEMus musculusApical plasma membrane17597763Antibody stainingA0A4X1W3F8_PIGSus scrofaApical plasma membrane26615917Antibody stainingPPB1_HUMANHomo sapiensApical plasma membrane10427087Antibody stainingPPB1_HUMANHomo sapiensApical plasma membrane10679012Membrane preparationGPI anchor and cholesterol rafts are necessary for apical sortingAMNLS_HUMANHomo sapiensApical plasma membrane14576052Antibody stainingAMNLS_MOUSEMus musculusApical plasma membrane15342463Antibody stainingAMNLS_MOUSEMus musculusApical plasma membrane15342463Antibody stainingAMNLS_MOUSEMus musculusApical plasma membrane15342463Antibody stainingA0A0G2K052_RATRattus norvegicusApical plasma membrane26313899Antibody stainingANO1_HUMANHomo sapiensApical plasma membrane25201006Antibody stainingF1PQ46_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsAMPN_HUMANHomo sapiensApical plasma membrane1980123Antibody stainingElectron micrographs show brush border localizationAMPN_PIGSus scrofaApical plasma membrane26615917Antibody stainingAPLP2_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredAQP1_MOUSEMus musculusNon polar membrane15859952Antibody stainingAQP1_MOUSEMus musculusApical plasma membrane25311759Antibody stainingAQP10_HUMANHomo sapiensApical plasma membrane15221416Antibody stainingAQP2_HUMANHomo sapiensApical plasma membrane19701945Antibody staining + sub-protein manipulationThe motif RRRxxxEL was identified as a sorting signalAQP2_MOUSEMus musculusApical plasma membrane11734858Antibody stainingAQP3_HUMANHomo sapiensBasolateral plasma membrane15221416Antibody stainingAQP3_HUMANHomo sapiensBasolateral plasma membrane15221416Antibody stainingAQP3_MOUSEMus musculusBasolateral plasma membrane20943764Antibody stainingAQP3_RATRattus norvegicusBasolateral plasma membrane7517548Antibody stainingAQP4_MOUSEMus musculusBasolateral plasma membrane10915655Antibody stainingAQP5_HUMANHomo sapiensNon polar membrane23473857Antibody stainingApical localization in sweat glands appears to be stimulus-dependentAQP5_HUMANHomo sapiensApical plasma membrane23473857Antibody stainingApical localization in sweat glands appears to be stimulus-dependentAQP5_MOUSEMus musculusApical plasma membrane23203809Antibody stainingCytoplasmic-to-apical translocation is stimulus-dependentAQP5_MOUSEMus musculusApical plasma membrane23473857Antibody stainingApical localization in sweat glands appears to be stimulus-dependentA0A0X1KG59_MOUSEMus musculusApical plasma membrane15859952Antibody stainingAQP9_RATRattus norvegicusApical plasma membrane11466204Antibody stainingAQP9_RATRattus norvegicusNon polar membrane11466204Antibody stainingAQP9_RATRattus norvegicusApical plasma membrane11466204Antibody stainingAREG_HUMANHomo sapiensBasolateral plasma membrane21917092Fluorescent tagging + sub-protein manipulationA monoleucine motif (EERKKLR) was responsible for basolateral targetingAREG_HUMANHomo sapiensBasolateral plasma membrane10362109Antibody staining + selective medium analysisARSA_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsASAH1_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredASGR1_MOUSEMus musculusBasolateral plasma membrane23979840Antibody stainingAT1A1_CANLFCanis lupus familiarisBasolateral plasma membrane16230337Membrane preparationEndogenous protein detected by selective biotinylationAT1A1_HUMANHomo sapiensApical plasma membrane16230337Membrane preparationEndogenous protein detected by selective biotinylationAT1A1_MOUSEMus musculusBasolateral plasma membrane17597763Antibody stainingAT1A1_PIGSus scrofaBasolateral plasma membrane16230337Membrane preparationEndogenous protein detected by selective biotinylationAT1B1_CANLFCanis lupus familiarisBasolateral plasma membrane16230337Membrane preparationEndogenous protein detected by selective biotinylationAT1B1_PIGSus scrofaBasolateral plasma membrane16230337Membrane preparationEndogenous protein detected by selective biotinylationAT1B1_RATRattus norvegicusBasolateral plasma membrane16230337Membrane preparationYFP was used as an immune epitope for detectionAT1B1_RATRattus norvegicusBasolateral plasma membrane16230337Membrane preparationYFP was used as an immune epitope for detection. Localization became apical onse additional N-glycosylation sites were addedAT1B2_HUMANHomo sapiensApical plasma membrane16230337Membrane preparationEndogenous protein detected by selective biotinylationAT1B2_RATRattus norvegicusBasolateral plasma membrane16230337Membrane preparationYFP was used as an immune epitope for detectionAT1B2_RATRattus norvegicusApical plasma membrane16230337Membrane preparationYFP was used as an immune epitope for detectionJ9P4S0_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsAT2B2_HUMANHomo sapiensNon polar membrane12624087Antibody staining + sub-protein manipulationApical localization is dependent on the alternative segment VKKGDGLQLPAADGAAASNAADSANASLVNGAT2B4_HUMANHomo sapiensBasolateral plasma membrane12624087Fluorescent taggingThe detected P23634-6 isoform only differs minimally from the canonical one.VPP4_HUMANHomo sapiensApical plasma membrane14638902Antibody stainingATP7B_RATRattus norvegicusBasolateral plasma membrane27034138Antibody stainingF1LUT4_RATRattus norvegicusApical plasma membrane27347675Antibody stainingAT8B1_HUMANHomo sapiensApical plasma membrane20512993Antibody stainingAT8B1_HUMANHomo sapiensApical plasma membrane11682026Antibody stainingAT8B1_MOUSEMus musculusApical plasma membrane15496606Antibody stainingAT8B1_MOUSEMus musculusApical plasma membrane15496606Antibody stainingATRN_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsNEU2_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredB2MG_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsBACE1_HUMANHomo sapiensApical plasma membrane11741885OtherA membrane side-specific biotinylation and purification scheme was followedF1PWJ7_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsBEST1_HUMANHomo sapiensBasolateral plasma membrane19853238Antibody stainingBPIA1_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredBPIB1_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredBASI_HUMANHomo sapiensNon polar membrane12657613Antibody stainingBASI_HUMANHomo sapiensApical plasma membrane16260747Antibody stainingBSND_MOUSEMus musculusBasolateral plasma membrane11734858Antibody stainingOther cochlear duct cells do not express barttinBSND_MOUSEMus musculusBasolateral plasma membrane11734858Antibody stainingBSND_MOUSEMus musculusBasolateral plasma membrane11734858Antibody stainingBSND_MOUSEMus musculusBasolateral plasma membrane11734858Antibody stainingBST2_HUMANHomo sapiensApical plasma membrane19273615Antibody stainingApical localization depends on ARHGAP44BST2_RATRattus norvegicusApical plasma membrane12956872Antibody stainingBTC_HUMANHomo sapiensBasolateral plasma membrane26272915Fluorescent tagging + sub-protein manipulationA monoleucine motif was identified as the basolateral signalC1QT5_MOUSEMus musculusNon polar membrane17122143Antibody stainingCAH12_HUMANHomo sapiensBasolateral plasma membrane15928319Antibody stainingCAH12_HUMANHomo sapiensBasolateral plasma membrane26911677Antibody stainingCAH12_HUMANHomo sapiensApical plasma membrane26911677Antibody stainingCAH12_HUMANHomo sapiensBasolateral plasma membrane26911677Antibody stainingCAH4_BOVINBos taurusApical plasma membrane18326729Antibody stainingCAH4_HUMANHomo sapiensApical plasma membrane8056514OtherAn activity-based histochemical method was usedCAH4_RABITOryctolagus cuniculusApical plasma membrane10836977Antibody stainingCAH4_RABITOryctolagus cuniculusApical plasma membrane10836977Antibody stainingCAH4_RABITOryctolagus cuniculusApical plasma membrane10836977Antibody stainingCAH4_RATRattus norvegicusApical plasma membrane2120700Antibody stainingCAC1D_MOUSEMus musculusApical plasma membrane31398491Antibody stainingA0A5F4D8V4_CANLFCanis lupus familiarisApical plasma membrane31142645Large-scale proteomicsCutoff: at least 80% apicalCD1D_HUMANHomo sapiensBasolateral plasma membrane9973405Antibody stainingCD320_HUMANHomo sapiensBasolateral plasma membrane9013602Membrane preparationI3LMQ0_PIGSus scrofaApical plasma membrane20950842Antibody stainingCD36_HUMANHomo sapiensApical plasma membrane20950842Antibody stainingCD36_MOUSEMus musculusApical plasma membrane21610069Antibody stainingEndocytosed after a fat-rich mealCD36_RATRattus norvegicusApical plasma membrane21610069Antibody stainingEndocytosed after a fat-rich mealCD44_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsCD44_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsDetected in the polarized exosome fractionDAF_HUMANHomo sapiensApical plasma membrane14530374Antibody stainingDAF_HUMANHomo sapiensNon polar membrane20688727Antibody stainingChimeric proteins were used. N-glycans were necessary for apical deliveryCD63_HUMANHomo sapiensBasolateral plasma membrane28031320Antibody stainingCD9_HUMANHomo sapiensApical plasma membrane18544636Antibody stainingCADH1_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsCADH1_CANLFCanis lupus familiarisBasolateral plasma membrane21228319Antibody stainingCADH1_CANLFCanis lupus familiarisBasolateral plasma membrane28768825Antibody stainingCADH1_RATRattus norvegicusBasolateral plasma membrane27210743Antibody stainingE2REV2_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsF1PAA3_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsCDHR2_HUMANHomo sapiensApical plasma membrane24725409Antibody stainingLinks the microvilli by binding CDHR5 (heterophilic)CDHR5_HUMANHomo sapiensApical plasma membrane24725409Antibody stainingLinks the microvilli by binding CDHR2 (heterophilic)Q004B2_CANLFCanis lupus familiarisApical plasma membrane31142645Large-scale proteomicsCutoff: at least 80% apicalCEAM1_HUMANHomo sapiensApical plasma membrane10436421Antibody stainingCEAM1_HUMANHomo sapiensApical plasma membrane20455097Antibody stainingCEAM1_HUMANHomo sapiensApical plasma membrane20455097Antibody stainingCEAM1_HUMANHomo sapiensApical plasma membrane20455097Antibody stainingCEAM1_MOUSEMus musculusApical plasma membrane25908210Antibody stainingCEA20_MOUSEMus musculusApical plasma membrane25908210Antibody stainingCEAM5_HUMANHomo sapiensApical plasma membrane10436421Antibody stainingCEAM6_HUMANHomo sapiensApical plasma membrane10436421Antibody stainingCEAM7_HUMANHomo sapiensApical plasma membrane10436421Antibody stainingA0A5F4D6S3_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsCFAB_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredCFAI_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredCFTR_HUMANHomo sapiensApical plasma membrane30975917Antibody stainingACM3_HUMANHomo sapiensBasolateral plasma membrane15870063Antibody staining + sub-protein manipulationA single dileucine-type motif was responsible for basolateral targetingF1S4D1_PIGSus scrofaApical plasma membrane22205680Antibody stainingF1S4D1_PIGSus scrofaApical plasma membrane22205680Antibody stainingNot expressed in goblet cellsCLCN2_MOUSEMus musculusBasolateral plasma membrane16155254Antibody stainingNot expressed in cryptsCLCN2_MOUSEMus musculusBasolateral plasma membrane16155254Antibody stainingCSTN1_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredCLTRN_MOUSEMus musculusApical plasma membrane17167413Antibody stainingCLUS_CANLFCanis lupus familiarisApical plasma membrane11673461Selective medium analysisSecretion depended on MAL proteinCNNM2_HUMANHomo sapiensBasolateral plasma membrane21397062Antibody stainingCNNM2_HUMANHomo sapiensBasolateral plasma membrane21397062Antibody stainingCNNM4_MOUSEMus musculusBasolateral plasma membrane24339795Antibody stainingCNNM4_MOUSEMus musculusBasolateral plasma membrane24339795Antibody stainingCOHA1_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsCOHA1_HUMANHomo sapiensBasolateral plasma membrane26967482Antibody stainingCOIA1_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Human Tissue AtlasCO4A1_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Tissue AtlasCO4A1_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Tissue AtlasCO4A1_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Tissue AtlasCO4A1_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Tissue AtlasCO4A1_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Tissue AtlasCO4A1_MOUSEMus musculusBasolateral plasma membrane19423686Antibody stainingForms a strict heterotrimer alpha1+alpha2+alpha1CO4A1_MOUSEMus musculusBasolateral plasma membrane19423686Antibody stainingCO4A2_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Tissue AtlasCO4A2_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Tissue AtlasCO4A2_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Tissue AtlasCO4A2_MOUSEMus musculusBasolateral plasma membrane19423686Antibody stainingForms a strict heterotrimer alpha1+alpha2+alpha1CO4A2_MOUSEMus musculusBasolateral plasma membrane19423686Antibody stainingCO4A3_MOUSEMus musculusBasolateral plasma membrane19423686Antibody stainingForms a strict heterotrimer alpha3+alpha4+alpha5CO4A4_MOUSEMus musculusBasolateral plasma membrane19423686Antibody stainingForms a strict heterotrimer alpha3+alpha4+alpha5Q63ZW6_MOUSEMus musculusBasolateral plasma membrane19423686Antibody stainingForms a strict heterotrimer alpha3+alpha4+alpha5CO7A1_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Human Tissue AtlasCO7A1_HUMANHomo sapiensBasolateral plasma membrane25613900Antibody stainingInferred from the Human Tissue AtlasCOMT_HUMANHomo sapiensApical plasma membrane17549793Large-scale proteomicsCutoff: at least 4-fold enrichment (A/total) at any repetitionCERU_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredCBPO_HUMANHomo sapiensApical plasma membrane21921028Antibody stainingAlso detected in D. rerio (fish) enterocytes apicallyCRUM1_MOUSEMus musculusApical plasma membrane15316081Antibody stainingCRUM2_MOUSEMus musculusApical plasma membrane27870829Antibody stainingDetected in developing mouse embryosCRUM2_MOUSEMus musculusApical plasma membrane23001562Antibody stainingCRUM3_MOUSEMus musculusApical plasma membrane24164893Antibody stainingDetected in developing mouse embryosCRUM3_MOUSEMus musculusApical plasma membrane24164893Antibody stainingDetected in developing mouse embryosCYTC_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredCATB_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsCATC_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredCATD_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsCATZ_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsCUBN_MOUSEMus musculusApical plasma membrane15342463Antibody stainingThe apical localization of cubilin is dependent on heteromerization with amnionlessCXAR_HUMANHomo sapiensBasolateral plasma membrane22343291Fluorescent tagging + sub-protein manipulationThe source of plasmid was not mentioned explicitly. A Tyr-based motif was confirmed to direct sorting.CXAR_HUMANHomo sapiensBasolateral plasma membrane10187807Functional assayViral infectivity assays were used in addition to antibody labellings of endogenous proteinIL8_BOVINBos taurusNon polar membrane25740541Selective medium analysisIL8_HUMANHomo sapiensNon polar membrane10603405Selective medium analysisIL8_HUMANHomo sapiensApical plasma membrane20711426Selective medium analysisDAG1_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsA0A5F4CJJ0_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsThe dog gene is incomplete at its N-terminus (due to poor genome sequence quality)DPEP1_PIGSus scrofaApical plasma membrane15456847Antibody stainingDPEP1_PIGSus scrofaApical plasma membrane15456847Antibody stainingDPP4_HUMANHomo sapiensApical plasma membrane17549793Large-scale proteomicsCutoff: at least 4-fold enrichment (A/total) at any repetitionDPP4_HUMANHomo sapiensApical plasma membrane16723498Antibody stainingDPP4_MOUSEMus musculusApical plasma membrane17597763Antibody stainingApical localization dependent on Rab8DPP4_RATRattus norvegicusApical plasma membrane1684792Antibody stainingDRAM2_MOUSEMus musculusApical plasma membrane25983245Antibody stainingDRAM2_MOUSEMus musculusApical plasma membrane25983245Antibody stainingDSC3_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredDUOX1_HUMANHomo sapiensApical plasma membrane10806195Antibody stainingDUOX2_HUMANHomo sapiensApical plasma membrane15591162Antibody stainingDUOX2_PIGSus scrofaApical plasma membrane15591162Antibody stainingDUOX2_PIGSus scrofaApical plasma membrane15591162Antibody stainingDUOX2_PIGSus scrofaApical plasma membrane15591162Antibody stainingF1PF03_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsThe dog gene is incomplete at its N-terminus (due to poor genome sequence quality)MUCEN_MOUSEMus musculusApical plasma membrane26831939Antibody stainingEMP2_MOUSEMus musculusApical plasma membrane16487956Antibody stainingF1PQA0_CANLFCanis lupus familiarisApical plasma membrane31142645Large-scale proteomicsCutoff: at least 80% apical. The dog protein is incomplete in UniProtF6XRM5_CANLFCanis lupus familiarisApical plasma membrane31142645Large-scale proteomicsCutoff: at least 80% apicalENPP1_MOUSEMus musculusBasolateral plasma membrane11598187Antibody stainingA non-canonical dileucine motif was responsible for basolateral sortingENPP3_HUMANHomo sapiensApical plasma membrane15072822Antibody stainingENPP3_RATRattus norvegicusApical plasma membrane11598187Antibody stainingENTP1_HUMANHomo sapiensApical plasma membrane15890655Antibody stainingF1PM51_CANLFCanis lupus familiarisBasolateral plasma membrane32531288Large-scale proteomicsThe dog gene is incomplete at its N-terminus (due to poor genome sequence quality)E2R6A6_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsA0A5F4D9M8_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsEPO_HUMANHomo sapiensApical plasma membrane8050502Selective medium analysisN-glycosylation is required for polarized sortingERBB2_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsERBB2_HUMANHomo sapiensBasolateral plasma membrane12646923Antibody stainingF1PVC5_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsEREG_HUMANHomo sapiensBasolateral plasma membrane23671122Fluorescent tagging + sub-protein manipulationSorting depended on a Tyr-based signalERP29_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsFBLN1_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredFCGBP_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredFCG2B_HUMANHomo sapiensBasolateral plasma membrane8039492Membrane preparation + sub-protein manipulationThe source of plasmid is not mentionedFINC_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredG3V8M6_RATRattus norvegicusApical plasma membrane1996614Antibody stainingA0A5F4CJI0_CANLFCanis lupus familiarisApical plasma membrane31142645Large-scale proteomicsCutoff: at least 80% apicalFSHR_HUMANHomo sapiensBasolateral plasma membrane9660834Antibody staining + sub-protein manipulationBasolateral localization depended in the Tyr-based YILV motifFSTL1_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsFSTL1_MOUSEMus musculusApical plasma membrane27355685Selective medium analysisFURIN_HUMANHomo sapiensBasolateral plasma membrane10082580Antibody staining + sub-protein manipulationA Tyrosine-based (YKGL) and a dileucine-type motif (ERTAFI) were responsible for basolateral targetingFUT6_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredPLM_RATRattus norvegicusApical plasma membrane12657675Antibody stainingA subunit of the Na+/K+ ATPase that is unusually apical in choroid plexusATNG_RATRattus norvegicusBasolateral plasma membrane16371442Antibody stainingNa+/K+ ATPase is usually basolateral save a few tissuesFXYD3_MOUSEMus musculusBasolateral plasma membrane16371442Antibody stainingNa+/K+ ATPase is usually basolateral save a few tissuesFXYD4_RATRattus norvegicusBasolateral plasma membrane16371442Antibody stainingNa+/K+ ATPase is usually basolateral save a few tissuesFXYD5_MOUSEMus musculusBasolateral plasma membrane16371442Antibody stainingNa+/K+ ATPase is usually basolateral save a few tissuesGALT2_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsGDF15_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredGGH_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsGGT1_HUMANHomo sapiensApical plasma membrane28993506Antibody stainingGGT1_HUMANHomo sapiensApical plasma membrane16799980Antibody stainingApical localization depends on ATP8B1GNS_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsGP2_RATRattus norvegicusApical plasma membrane8772516Membrane preparationE2QUR6_CANLFCanis lupus familiarisApical plasma membrane31142645Large-scale proteomicsCutoff: at least 80% apicalGP143_HUMANHomo sapiensApical plasma membrane18828673Antibody stainingF1PHN5_CANLFCanis lupus familiarisApical plasma membrane31142645Large-scale proteomicsF1CMF1_CANLFCanis lupus familiarisApical plasma membrane31142645Large-scale proteomicsCutoff: at least 80% apicalHEXB_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredHLAA_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsHEPS_MOUSEMus musculusApical plasma membrane26673890Antibody stainingENPL_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsHYOU1_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredIBP2_HUMANHomo sapiensBasolateral plasma membrane7542277Selective medium analysisEndogenous protein was detectedIBP2_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredIBP2_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsIBP3_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsIBP4_HUMANHomo sapiensBasolateral plasma membrane7542277Selective medium analysisEndogenous protein was detectedIBP6_HUMANHomo sapiensApical plasma membrane7542277Selective medium analysisEndogenous protein was detectedIBP6_MOUSEMus musculusApical plasma membrane18824213Selective medium analysisO-glycosylation did affect sorting but it was already apical in its absenceIBP7_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredIGSF5_RATRattus norvegicusApical plasma membrane16118391Antibody stainingIL2RA_HUMANHomo sapiensApical plasma membrane15870063Antibody stainingProteins were tagged by FLAG-tag for labellingIL6_BOVINBos taurusApical plasma membrane25740541Selective medium analysisIL6_HUMANHomo sapiensApical plasma membrane32062016Selective medium analysisIL6_HUMANHomo sapiensApical plasma membrane20711426Selective medium analysisIL6RA_HUMANHomo sapiensBasolateral plasma membrane11017875Antibody staining + sub-protein manipulationThe basolateral determinant resided somwehere in the cytoplasmic segmentIL6RB_HUMANHomo sapiensBasolateral plasma membrane16274960Membrane preparationContains a dileucine-type signal that is modified by phosphorylationINSR_HUMANHomo sapiensBasolateral plasma membrane7926303Membrane preparationINSR_RATRattus norvegicusBasolateral plasma membrane8069944Antibody stainingE2REA9_CANLFCanis lupus familiarisBasolateral plasma membrane32531288Large-scale proteomicsITA2_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsDetected in the polarized exosome fractionF1Q439_CANLFCanis lupus familiarisBasolateral plasma membrane32531288Large-scale proteomicsITA3_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsDetected in the polarized exosome fractionA0A5F4CJ46_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsITA6_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsDetected in the polarized exosome fractionA0A5F4CIL4_CANLFCanis lupus familiarisBasolateral plasma membrane32531288Large-scale proteomicsITB1_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsDetected in the polarized exosome fractionITB4_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsDetected in the polarized exosome fractionKCNA1_MOUSEMus musculusApical plasma membrane19307729Antibody stainingKCNE1_RATRattus norvegicusApical plasma membrane2154581Antibody stainingKCNE1_RATRattus norvegicusApical plasma membrane2154581Antibody stainingKCNE1_RATRattus norvegicusApical plasma membrane2154581Antibody stainingKCNJ1_MOUSEMus musculusApical plasma membrane11734858Antibody stainingKCJ10_HUMANHomo sapiensBasolateral plasma membrane24561201Antibody stainingKCJ16_HUMANHomo sapiensBasolateral plasma membrane24561201Antibody stainingKCNJ4_MOUSEMus musculusBasolateral plasma membrane11504929Antibody stainingA VSV epitope was used for labelling. Localization was dependent on a PDZ motifKCNK1_HUMANHomo sapiensApical plasma membrane21964404Antibody stainingKCNK5_HUMANHomo sapiensApical plasma membrane21964404Antibody stainingKCNK6_HUMANHomo sapiensApical plasma membrane21964404Antibody stainingKCMA1_HUMANHomo sapiensApical plasma membrane11069304Membrane preparationLocalization is independent of glycosylationKCNQ1_HUMANHomo sapiensBasolateral plasma membrane21228319Antibody stainingKCNQ1_MOUSEMus musculusApical plasma membrane11734858Antibody stainingSCF_HUMANHomo sapiensBasolateral plasma membrane11152680Fluorescent tagging + sub-protein manipulationA monoleucine motif (NEISMLQ) was identifed as critical for basolateral sortingKLOT_MOUSEMus musculusApical plasma membrane15665504Antibody stainingKLOT_MOUSEMus musculusNon polar membrane15665504Antibody stainingKLK10_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsG1TR57_RABITOryctolagus cuniculusBasolateral plasma membrane9864376Antibody stainingLPH_HUMANHomo sapiensApical plasma membrane16488876Antibody stainingA Myc tag was used for labellingLDLR_HUMANHomo sapiensApical plasma membrane10535737Antibody stainingSource of vectors were not described properly. Expression of AP-1B causes basolateral sortingLDLR_HUMANHomo sapiensApical plasma membrane12134076Antibody stainingExpression of AP-1B causes basolateral sortingLDLR_HUMANHomo sapiensBasolateral plasma membrane10535737Antibody stainingSource of vectors were not describedLDLR_HUMANHomo sapiensBasolateral plasma membrane21444685Antibody stainingSource of vectors were not describedLDLR_MOUSEMus musculusBasolateral plasma membrane17597763Antibody stainingLSHR_PIGSus scrofaBasolateral plasma membrane14694083Antibody staining + sub-protein manipulationLocalization was mediated by the cytoplasmic tailA2GL_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredE2R4Q1_CANLFCanis lupus familiarisBasolateral plasma membrane19005208Antibody stainingEndogenous proteinLRP1_HUMANHomo sapiensBasolateral plasma membrane19005208Antibody staining + sub-protein manipulationA shortened LRP1 protein construct was used. Basolateral targeting relied on an NPxY-type sorting motifLRP1_HUMANHomo sapiensBasolateral plasma membrane19005208Antibody staining + sub-protein manipulationA shortened LRP1 protein construct was usedLRP2_HUMANHomo sapiensApical plasma membrane27180806Antibody stainingA HA tag was used for labelling the mini-receptorLRP2_MOUSEMus musculusApical plasma membrane15342463Antibody stainingLocalization did not depend on the AMNS-CUBN complexLRP2_RATRattus norvegicusApical plasma membrane15010355Antibody stainingF1PKT2_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsThe dog gene is incomplete at its N-terminus (due to poor genome sequence quality)LTBP4_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredTRFL_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredMAL_HUMANHomo sapiensApical plasma membrane9528996Antibody stainingMost of the protein is actually in the apical recycling endosome - not on surfaceMAL2_HUMANHomo sapiensApical plasma membrane12370246Antibody stainingMost of the protein is actually in the apical recycling endosome - not on surfaceTRFM_HUMANHomo sapiensApical plasma membrane17549793Large-scale proteomicsCutoff: at least 4-fold enrichment (A/total) at any repetitionMET_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsMET_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredA0A5F4C3L7_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsA0A5F4C4S9_CANLFCanis lupus familiarisApical plasma membrane17122143Antibody stainingMFRP_MOUSEMus musculusNon polar membrane17122143Antibody stainingMFS4B_RATRattus norvegicusApical plasma membrane12590146Membrane preparationMGA_HUMANHomo sapiensApical plasma membrane3143729Membrane preparationMICA_HUMANHomo sapiensBasolateral plasma membrane11854468Fluorescent tagging + sub-protein manipulationA dileucine-type motif (EGPELV) mediated sortingNEP_HUMANHomo sapiensApical plasma membrane16799980Antibody stainingApical localization depends on ATP8B1MMP10_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredMSLN_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredMUC1_HUMANHomo sapiensApical plasma membrane21937430Antibody staining + sub-protein manipulationThe O-glycans were found to be critical for apical targetingMUC13_HUMANHomo sapiensApical plasma membrane17549793Large-scale proteomicsCutoff: at least 4-fold enrichment (A/total) at any repetitionMUC13_HUMANHomo sapiensApical plasma membrane11278439Antibody stainingMUC13_HUMANHomo sapiensApical plasma membrane11278439Antibody stainingMUC13_HUMANHomo sapiensApical plasma membrane11278439Antibody stainingMUC13_HUMANHomo sapiensApical plasma membrane11278439Antibody stainingA0A140LJ72_MOUSEMus musculusApical plasma membrane18637025Antibody stainingA0A140LJ72_MOUSEMus musculusApical plasma membrane18637025Antibody stainingA0A140LJ72_MOUSEMus musculusApical plasma membrane18637025Antibody stainingA0A140LJ72_MOUSEMus musculusApical plasma membrane18637025Antibody stainingA0A140LJ72_MOUSEMus musculusApical plasma membrane18637025Antibody stainingA0A140LJ72_MOUSEMus musculusApical plasma membrane18637025Antibody stainingMUC2_MOUSEMus musculusApical plasma membrane29636525Antibody stainingMUC24_RATRattus norvegicusApical plasma membrane22855528Antibody stainingSialylated glycans and Galectin-9 was required for apical localizationMUC24_RATRattus norvegicusApical plasma membrane22855528Antibody stainingMUC4_HUMANHomo sapiensApical plasma membrane12748185Antibody stainingSource of the expression plasmid is not mentioned but it is likely humanMUC5A_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredMUC5B_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredNALDL_RATRattus norvegicusNon polar membrane9388249Antibody stainingNALDL_RATRattus norvegicusApical plasma membrane9388249Antibody stainingNAGAB_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsTNR16_HUMANHomo sapiensApical plasma membrane28768825Antibody stainingTNR16_RATRattus norvegicusApical plasma membrane9362511Antibody stainingNRG1_HUMANHomo sapiensApical plasma membrane12646923Antibody staining5NTD_HUMANHomo sapiensApical plasma membrane16723498Antibody stainingOTOAN_MOUSEMus musculusApical plasma membrane11972037Antibody stainingOTOG_MOUSEMus musculusApical plasma membrane11506947Antibody stainingP2RX4_MOUSEMus musculusApical plasma membrane30746715Antibody stainingPDIA1_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsPANX1_MOUSEMus musculusApical plasma membrane31102595Fluorescent taggingPDIA4_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsPDPN_RATRattus norvegicusApical plasma membrane15009093Antibody stainingPDPN_RATRattus norvegicusApical plasma membrane15009093Antibody stainingElectron micrographs were used to clarify localizationF1PHD1_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsThe N-terminus of the dog protein is incorrectly extened in UniProtPIGR_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredPIP_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsUROK_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredPLB1_RATRattus norvegicusApical plasma membrane9442064Membrane preparationPLET1_PIGSus scrofaApical plasma membrane27941613Antibody stainingA0A5F4BSS4_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsThe N-terminus of the dog protein is incorrectly extened in UniProtE2RM56_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsF1P9S5_CANLFCanis lupus familiarisBasolateral plasma membrane32531288Large-scale proteomicsPLXB2_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsDetected in the polarized exosome fractionPODXL_CANLFCanis lupus familiarisApical plasma membrane31142645Large-scale proteomicsPODXL_HUMANHomo sapiensApical plasma membrane29968174Antibody stainingPODXL_HUMANHomo sapiensApical plasma membrane20332120Antibody stainingGLU2B_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsPROM1_HUMANHomo sapiensApical plasma membrane18645205Antibody stainingPROM1_HUMANHomo sapiensApical plasma membrane18645205Antibody stainingPROM1_HUMANHomo sapiensApical plasma membrane18645205Antibody stainingPROM1_HUMANHomo sapiensApical plasma membrane18645205Antibody stainingPROM1_HUMANHomo sapiensApical plasma membrane18645205Antibody stainingPROM2_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsPRSS8_MOUSEMus musculusApical plasma membrane26673890Antibody stainingSAP_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsFPRP_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsPTPRH_MOUSEMus musculusApical plasma membrane19170756Antibody stainingGoblet cells do not express this proteinF1P983_CANLFCanis lupus familiarisApical plasma membrane32531288Large-scale proteomicsPTPRO_MOUSEMus musculusApical plasma membrane10792603Antibody stainingQ62797_RATRattus norvegicusApical plasma membrane17086182Antibody stainingTIG1_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredRHBG_MOUSEMus musculusBasolateral plasma membrane12388412Antibody stainingRHCG_MOUSEMus musculusApical plasma membrane12388412Antibody stainingRRBP1_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsSCRB1_HUMANHomo sapiensApical plasma membrane17549793Large-scale proteomicsCutoff: at least 4-fold enrichment (A/total) at any repetitionUTER_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredUTER_MOUSEMus musculusApical plasma membrane27355685Antibody stainingUTER_RABITOryctolagus cuniculusNon polar membrane8375500Selective medium analysisUTER_RABITOryctolagus cuniculusBasolateral plasma membrane8375500Selective medium analysisSG1D2_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredSCN2B_HUMANHomo sapiensApical plasma membrane31511323Fluorescent taggingSCNNA_HUMANHomo sapiensApical plasma membrane28130590Antibody stainingSCNNA_MOUSEMus musculusApical plasma membrane12925696Antibody stainingSCNNB_HUMANHomo sapiensApical plasma membrane28130590Antibody stainingSCNNB_MOUSEMus musculusApical plasma membrane12925696Antibody stainingSCNNG_HUMANHomo sapiensApical plasma membrane28130590Antibody stainingSCNNG_MOUSEMus musculusApical plasma membrane12925696Antibody stainingSDC1_MOUSEMus musculusBasolateral plasma membrane18764819Antibody stainingLocalization depends on PDZ motif. A Myc epitope was used for labellingCAB45_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsF1P9X5_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsA1AT_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredAACT_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredCBG_HUMANHomo sapiensApical plasma membrane10356976Selective medium analysisAbsence of N-glycans do not affect polarized sortingPEDF_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsB5THE3_MOUSEMus musculusApical plasma membrane17597763Antibody stainingApical localization dependent on Rab8SUIS_HUMANHomo sapiensApical plasma membrane10359703Membrane preparationDetected by western blotting the apical or basolateral membrane preparatesSUIS_HUMANHomo sapiensApical plasma membrane16488876Fluorescent taggingSUIS_HUMANHomo sapiensApical plasma membrane17549793Large-scale proteomicsCutoff: at least 4-fold enrichment (A/total) at any repetitionNTCP2_MOUSEMus musculusApical plasma membrane15563450Antibody stainingNTCP2_RATRattus norvegicusApical plasma membrane9389734Antibody stainingNTCP2_RATRattus norvegicusApical plasma membrane9389734Antibody stainingNRAM2_HUMANHomo sapiensNon polar membrane20007457OtherA membrane side-specific biotinylation and purification scheme was followedNRAM2_RATRattus norvegicusApical plasma membrane20007457Antibody stainingLocalization is dynamicS12A1_MOUSEMus musculusApical plasma membrane25967121Antibody stainingQ9QX10_RATRattus norvegicusApical plasma membrane15356425Antibody stainingS12A2_MOUSEMus musculusApical plasma membrane30576237Antibody stainingS12A2_MOUSEMus musculusBasolateral plasma membrane16155254Antibody stainingS12A2_MOUSEMus musculusBasolateral plasma membrane16155254Antibody stainingS12A3_HUMANHomo sapiensApical plasma membrane21397062Antibody stainingS12A3_MOUSEMus musculusApical plasma membrane12388412Antibody stainingS12A3_MOUSEMus musculusApical plasma membrane14576148Antibody stainingS12A3_MOUSEMus musculusApical plasma membrane30007527Antibody stainingS12A3_MOUSEMus musculusApical plasma membrane25498502Antibody stainingS12A7_RATRattus norvegicusBasolateral plasma membrane24089410Antibody stainingE2RMJ3_CANLFCanis lupus familiarisApical plasma membrane23698785Antibody stainingS15A1_MOUSEMus musculusApical plasma membrane17597763Antibody stainingApical localization dependent on Rab8F1PCQ3_CANLFCanis lupus familiarisBasolateral plasma membrane16260747Antibody stainingBasigin can control localization of MOT1F1PCQ3_CANLFCanis lupus familiarisBasolateral plasma membrane32531288Large-scale proteomicsMOT1_HUMANHomo sapiensBasolateral plasma membrane21199217Fluorescent tagging + sub-protein manipulationMOT1_HUMANHomo sapiensApical plasma membrane15901598Membrane preparationMOT1_HUMANHomo sapiensApical plasma membrane16260747Antibody stainingMOT1_HUMANHomo sapiensApical plasma membrane12657613Antibody stainingMOT1_HUMANHomo sapiensApical plasma membrane15901598Membrane preparationMOT1_MOUSEMus musculusApical plasma membrane31594969Antibody stainingMOT1_RATRattus norvegicusNon polar membrane18619525Antibody stainingMOT10_MOUSEMus musculusBasolateral plasma membrane16245314Antibody stainingMOT10_MOUSEMus musculusBasolateral plasma membrane16245314Antibody stainingMOT10_MOUSEMus musculusBasolateral plasma membrane16245314Antibody stainingMOT8_MOUSEMus musculusApical plasma membrane18687783Antibody stainingMOT8_RATRattus norvegicusApical plasma membrane18687783Antibody stainingJ9NVM8_CANLFCanis lupus familiarisBasolateral plasma membrane16260747Antibody stainingMOT4_HUMANHomo sapiensBasolateral plasma membrane21199217Fluorescent tagging + sub-protein manipulationTwo basolateral signals were identified in the cytoplasmic tailMOT4_HUMANHomo sapiensBasolateral plasma membrane15901598Membrane preparationMOT4_HUMANHomo sapiensBasolateral plasma membrane12657613Antibody stainingMOT4_HUMANHomo sapiensBasolateral plasma membrane15901598Membrane preparationMOT5_HUMANHomo sapiensBasolateral plasma membrane15901598Membrane preparationMOT5_HUMANHomo sapiensBasolateral plasma membrane15901598Membrane preparationF1P8F7_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsMOT3_HUMANHomo sapiensBasolateral plasma membrane16260747Antibody stainingMOT3_HUMANHomo sapiensBasolateral plasma membrane21199217Fluorescent tagging + sub-protein manipulationTwo basolateral signals were identified in the cytoplasmic tailMOT3_HUMANHomo sapiensBasolateral plasma membrane15901598Membrane preparationMOT3_HUMANHomo sapiensBasolateral plasma membrane16260747Antibody stainingMOT3_HUMANHomo sapiensBasolateral plasma membrane12657613Antibody stainingMOT3_HUMANHomo sapiensBasolateral plasma membrane15901598Membrane preparationNPT1_HUMANHomo sapiensApical plasma membrane25252215Antibody stainingNPT4_HUMANHomo sapiensApical plasma membrane20810651Antibody stainingS17A4_HUMANHomo sapiensApical plasma membrane22460716Antibody stainingS17A4_MOUSEMus musculusApical plasma membrane22460716Antibody stainingEAA3_HUMANHomo sapiensApical plasma membrane12486157Fluorescent taggingThe source of plasmids is unclear. An unusal apical sorting signal has been identified (KSYVNGGFAVD)EAA3_HUMANHomo sapiensApical plasma membrane21123949Antibody stainingEAA3_RATRattus norvegicusApical plasma membrane9435692Antibody stainingEAA2_HUMANHomo sapiensNon polar membrane12486157Fluorescent taggingThe source of plasmids is not mentioned but likely humanEAA1_HUMANHomo sapiensBasolateral plasma membrane12486157Fluorescent taggingThe source of plasmids is not mentioned but likely humanAAAT_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsS22A1_RATRattus norvegicusBasolateral plasma membrane10997918Antibody stainingS22AB_HUMANHomo sapiensApical plasma membrane15037815Antibody stainingS22AB_HUMANHomo sapiensApical plasma membrane16236806Antibody stainingApical localization was modulated by NHERF-family protein binding (through a PDZ motif)S22AC_MOUSEMus musculusApical plasma membrane24156345Antibody stainingS22AC_MOUSEMus musculusApical plasma membrane28679589Antibody stainingB2GV36_RATRattus norvegicusApical plasma membrane18411268Membrane preparationExpression was gender-dependentS22A2_HUMANHomo sapiensBasolateral plasma membrane16807400Antibody stainingS22A2_HUMANHomo sapiensBasolateral plasma membrane28031320Antibody stainingS22A2_MOUSEMus musculusBasolateral plasma membrane28031320Antibody stainingLocalization depended on the presence of CD63S22A2_RATRattus norvegicusBasolateral plasma membrane10997918Antibody stainingS22A3_HUMANHomo sapiensApical plasma membrane16263091Antibody stainingG1SJV5_RABITOryctolagus cuniculusApical plasma membrane18641280Antibody stainingS22A4_HUMANHomo sapiensApical plasma membrane18641280Membrane preparationS22A4_MOUSEMus musculusApical plasma membrane20601551Antibody stainingA0A5F9CMA4_RABITOryctolagus cuniculusApical plasma membrane18641280Antibody stainingS22A5_HUMANHomo sapiensApical plasma membrane18641280Membrane preparationS22A5_HUMANHomo sapiensApical plasma membrane16807400Antibody stainingS22A5_MOUSEMus musculusApical plasma membrane16896066Antibody stainingApical localization is modulated by NHERF4 bindingS22A6_HUMANHomo sapiensBasolateral plasma membrane15037815Antibody stainingS22A6_MOUSEMus musculusBasolateral plasma membrane23389457Antibody stainingS22A6_RATRattus norvegicusBasolateral plasma membrane15010355Antibody stainingS22A8_HUMANHomo sapiensBasolateral plasma membrane15037815Antibody stainingS22A8_MOUSEMus musculusBasolateral plasma membrane23389457Antibody stainingS22A8_RATRattus norvegicusBasolateral plasma membrane15010355Antibody stainingS22A8_RATRattus norvegicusBasolateral plasma membrane15010355Antibody stainingS22A8_RATRattus norvegicusBasolateral plasma membrane18619525Antibody stainingS23A1_HUMANHomo sapiensApical plasma membrane23837633Fluorescent tagging + sub-protein manipulationS23A2_HUMANHomo sapiensBasolateral plasma membrane23837633Fluorescent tagging + sub-protein manipulationBasolateral localization depends on classical dileucine-type motif EDTELMS23A2_MOUSEMus musculusBasolateral plasma membrane31594969Antibody stainingLocalization of transporter is labile: It can redistribute to vesiclesS26A1_RATRattus norvegicusBasolateral plasma membrane27210743Antibody stainingS26A1_RATRattus norvegicusNon polar membrane27210743Antibody stainingS26A2_HUMANHomo sapiensApical plasma membrane11457925Antibody stainingS26A2_HUMANHomo sapiensNon polar membrane11457925Antibody stainingStaining is mostly intracellularS26A2_HUMANHomo sapiensApical plasma membrane11457925Antibody stainingS26A2_HUMANHomo sapiensNon polar membrane11457925Antibody stainingStaining is mostly intracellularS26A2_RATRattus norvegicusApical plasma membrane20369363Antibody stainingS26A3_HUMANHomo sapiensApical plasma membrane22159084Antibody stainingHA tag was used for labelling. N-glylosylation had an effect on proteolytic stability but not apical targetingS26A4_HUMANHomo sapiensApical plasma membrane14715652Functional assayA heterologously expressed transporter assay was usedS26A4_HUMANHomo sapiensApical plasma membrane15942636Antibody stainingS26A4_MOUSEMus musculusApical plasma membrane12925556Antibody stainingS26A4_MOUSEMus musculusApical plasma membrane12925556Antibody stainingS26A4_MOUSEMus musculusApical plasma membrane12388412Antibody stainingS26A4_MOUSEMus musculusApical plasma membrane22243245Antibody stainingS26A5_MOUSEMus musculusBasolateral plasma membrane25596279Antibody stainingGerbil prestin was also found to localize basolaterally when transfected into MDCK cellsS26A6_MOUSEMus musculusApical plasma membrane29530983Antibody stainingS26A6_MOUSEMus musculusApical plasma membrane18496516Antibody stainingA0A1W2Q610_RATRattus norvegicusBasolateral plasma membrane12965893Antibody stainingNot expressed in the principal cells of the collecting ductG1TX36_RABITOryctolagus cuniculusApical plasma membrane11834742Antibody stainingS27A2_HUMANHomo sapiensApical plasma membrane28993506Antibody stainingS28A1_RATRattus norvegicusApical plasma membrane11292631Fluorescent taggingS28A1_RATRattus norvegicusApical plasma membrane11292631Fluorescent taggingLocation was also confirmed by a functional transport assayS28A2_RATRattus norvegicusApical plasma membrane11292631Fluorescent taggingS28A2_RATRattus norvegicusApical plasma membrane11292631Fluorescent taggingLocation was also confirmed by a functional transport assayS29A1_HUMANHomo sapiensBasolateral plasma membrane12527552Fluorescent taggingS29A2_HUMANHomo sapiensBasolateral plasma membrane12527552Fluorescent taggingS29A4_HUMANHomo sapiensApical plasma membrane23255610Antibody stainingGTR1_HUMANHomo sapiensBasolateral plasma membrane14605095Antibody stainingGTR1_HUMANHomo sapiensBasolateral plasma membrane1502167Antibody stainingEndogenous proteinsGTR1_HUMANHomo sapiensNon polar membrane12657613Antibody stainingGTR1_MOUSEMus musculusBasolateral plasma membrane31594969Antibody stainingGTR1_RABITOryctolagus cuniculusBasolateral plasma membrane9092796Antibody staining + sub-protein manipulationThe large intracellular loop was identified as a determinat of sortingGTR1_RATRattus norvegicusBasolateral plasma membrane16091581Antibody stainingGTR1_RATRattus norvegicusBasolateral plasma membrane12483288Antibody stainingGTR1_RATRattus norvegicusNon polar membrane8069944Antibody stainingGTR1_RATRattus norvegicusNon polar membrane18619525Antibody stainingD3ZNG4_RATRattus norvegicusApical plasma membrane16091581Antibody stainingD3ZNG4_RATRattus norvegicusApical plasma membrane16091581Antibody stainingD3ZNG4_RATRattus norvegicusApical plasma membrane12483288Antibody stainingGTR12_HUMANHomo sapiensApical plasma membrane16091581Antibody stainingGTR12_HUMANHomo sapiensApical plasma membrane16091581Antibody stainingGTR2_HUMANHomo sapiensBasolateral plasma membrane14605095Antibody stainingGTR3_HUMANHomo sapiensApical plasma membrane14605095Antibody staining + sub-protein manipulationThe sequence DRSGKDGVMEMN preceding the PDZ motif was identified as the apical determinantGTR3_HUMANHomo sapiensApical plasma membrane20007457OtherA membrane side-specific biotinylation and purification scheme was followedGTR3_HUMANHomo sapiensApical plasma membrane1502167Antibody stainingEndogenous proteinsGTR3_MOUSEMus musculusApical plasma membrane9108057Antibody stainingGTR5_MOUSEMus musculusApical plasma membrane18496516Antibody stainingGTR5_RATRattus norvegicusApical plasma membrane14605095Antibody stainingGTR5_RATRattus norvegicusApical plasma membrane9092796Antibody staining + sub-protein manipulationThe large intracellular loop was identified as a determinat of sortingGTR9_HUMANHomo sapiensBasolateral plasma membrane23361362Antibody stainingThe shorter isoform carries a unique apical determinant (MKLSKKDRGEDEESDSAKKKL) on its N-terminusZNT5_HUMANHomo sapiensApical plasma membrane11937503Antibody stainingA Myc-tag was used for labellingNPT2A_HUMANHomo sapiensApical plasma membrane26047794Fluorescent taggingNPT2B_HUMANHomo sapiensApical plasma membrane22904329Fluorescent taggingApical localization depended on the C-terminal PDZ motif and its interaction with NHERFNPT2B_MOUSEMus musculusApical plasma membrane10564169Antibody stainingNPT2B_RATRattus norvegicusApical plasma membrane22904329Antibody stainingNPT2C_MOUSEMus musculusApical plasma membrane21388960Antibody stainingOnly seen in a small subpopulation of proximal tubules. Apical localization depends on binding to NHERFQ8WMR9_CANLFCanis lupus familiarisApical plasma membrane31142645Large-scale proteomicsS36A1_MOUSEMus musculusApical plasma membrane20377526Antibody stainingExpression is limited to the initial segment of tubulesS36A2_HUMANHomo sapiensApical plasma membrane19033659Antibody stainingS36A2_MOUSEMus musculusApical plasma membrane20377526Antibody stainingS39A4_MOUSEMus musculusApical plasma membrane15322118Antibody stainingOverexpressed. HA tag was used for labellingS39A5_MOUSEMus musculusBasolateral plasma membrane15322118Antibody stainingOverexpressed. HA tag was used for labellingSLC31_MOUSEMus musculusApical plasma membrane12167606OtherCovalently linked heterodimer with SLC7A9: was detected with co-purification4F2_HUMANHomo sapiensApical plasma membrane11742812Antibody staining4F2_MOUSEMus musculusBasolateral plasma membrane15155792Antibody staining4F2_MOUSEMus musculusBasolateral plasma membrane15155792Antibody stainingX5IHJ5_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsCutoff: at least 80% basolateralS40A1_HUMANHomo sapiensNon polar membrane20007457OtherA membrane side-specific biotinylation and purification scheme was followedS40A1_MOUSEMus musculusBasolateral plasma membrane16054062Antibody stainingS40A1_MOUSEMus musculusBasolateral plasma membrane16054062Antibody stainingS40A1_RATRattus norvegicusNon polar membrane20007457Antibody stainingLocalization is dynamicS41A1_MOUSEMus musculusBasolateral plasma membrane30417250Antibody stainingAn HA tag was used for labellingE2R949_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsF1PG85_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsCTL4_HUMANHomo sapiensApical plasma membrane24379411Fluorescent taggingS47A1_HUMANHomo sapiensApical plasma membrane16807400Antibody stainingS47A2_HUMANHomo sapiensApical plasma membrane16807400Antibody stainingB3AT_RATRattus norvegicusBasolateral plasma membrane2526338Antibody stainingB3AT_RATRattus norvegicusBasolateral plasma membrane12965893Antibody stainingS4A11_HUMANHomo sapiensApical plasma membrane17715183Antibody stainingS4A11_HUMANHomo sapiensNon polar membrane17715183Antibody stainingS4A11_HUMANHomo sapiensApical plasma membrane17715183Antibody stainingS4A11_HUMANHomo sapiensApical plasma membrane17715183Antibody stainingB3A2_MOUSEMus musculusApical plasma membrane25311759Antibody stainingB3A2_MOUSEMus musculusApical plasma membrane18362326Antibody stainingS4A4_HUMANHomo sapiensBasolateral plasma membrane15273250Fluorescent taggingBasolateral localization depended on the dileucine-type motif EQQPFLS4A4_HUMANHomo sapiensNon polar membrane17715183Antibody stainingS4A4_MOUSEMus musculusBasolateral plasma membrane18362326Antibody stainingS4A5_HUMANHomo sapiensApical plasma membrane17715183Antibody stainingS4A7_HUMANHomo sapiensNon polar membrane17715183Antibody stainingS4A7_HUMANHomo sapiensNon polar membrane17715183Antibody stainingOSTA_MOUSEMus musculusBasolateral plasma membrane15563450Antibody stainingPart of a heteromeric OSTA-OSTB complexOSTB_MOUSEMus musculusBasolateral plasma membrane15563450Antibody stainingPart of a heteromeric OSTA-OSTB complexS52A3_HUMANHomo sapiensApical plasma membrane21512156Fluorescent taggingSC5A1_PIGSus scrofaApical plasma membrane21030609Antibody stainingSC5A1_RATRattus norvegicusApical plasma membrane16204409Antibody stainingSC5A1_RATRattus norvegicusApical plasma membrane16204409Antibody stainingSC5AC_MOUSEMus musculusApical plasma membrane17692818Antibody stainingSC5A2_MOUSEMus musculusApical plasma membrane25268124Antibody stainingSC5A5_HUMANHomo sapiensBasolateral plasma membrane10576759Antibody stainingSC5A8_HUMANHomo sapiensApical plasma membrane15001644Antibody stainingSC5A8_MOUSEMus musculusApical plasma membrane17692818Antibody stainingS6A18_MOUSEMus musculusApical plasma membrane20377526Antibody stainingS6A19_MOUSEMus musculusApical plasma membrane17167413Antibody stainingS6A20_HUMANHomo sapiensApical plasma membrane19033659Antibody stainingS620A_MOUSEMus musculusApical plasma membrane20377526Antibody stainingLAT1_HUMANHomo sapiensApical plasma membrane11742812Antibody stainingLAT1_RATRattus norvegicusNon polar membrane18619525Antibody stainingYLAT1_HUMANHomo sapiensBasolateral plasma membrane28495876Antibody stainingThe antibody HPA036227 was used to detect SLC7A7 in kidney (also in the tissue atlas)YLAT1_MOUSEMus musculusBasolateral plasma membrane15155792Antibody stainingLAT2_MOUSEMus musculusBasolateral plasma membrane15155792Antibody stainingLAT2_MOUSEMus musculusBasolateral plasma membrane15155792Antibody stainingBAT1_HUMANHomo sapiensApical plasma membrane11318953Antibody stainingCovalently linked heterodimer with SLC3A1NAC1_MOUSEMus musculusBasolateral plasma membrane25498502Antibody stainingNAC2_MOUSEMus musculusBasolateral plasma membrane25498502Antibody stainingSL9A3_MOUSEMus musculusApical plasma membrane18046080Antibody stainingSL9A3_RABITOryctolagus cuniculusApical plasma membrane15226406Fluorescent taggingF6XZG7_CANLFCanis lupus familiarisBasolateral plasma membrane22948142Antibody stainingDetecting endogenous proteinsSO1B3_HUMANHomo sapiensBasolateral plasma membrane10779507Antibody stainingSO1B3_HUMANHomo sapiensBasolateral plasma membrane10779507Antibody stainingSO1C1_MOUSEMus musculusNon polar membrane18687783Antibody stainingSO1C1_RATRattus norvegicusNon polar membrane18687783Antibody stainingF1Q4K7_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsST14_HUMANHomo sapiensBasolateral plasma membrane32049977Fluorescent tagging + sub-protein manipulationA dileucine-type motif (EEGEVFL) was required for basolateral localizationA0A5F4C7U1_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsThe N-terminus of the dog protein is incorrectly extened in UniProtJ9NWI0_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsA0A5F4D2S3_CANLFCanis lupus familiarisApical plasma membrane15623527Antibody stainingThe dog syntaxin 3 gene is inappropriately assembledSTX4_HUMANHomo sapiensBasolateral plasma membrane29968174Large-scale proteomicsSTX4_HUMANHomo sapiensBasolateral plasma membrane29968174Antibody stainingSUSD2_HUMANHomo sapiensApical plasma membrane17549793Large-scale proteomicsCutoff: at least 4-fold enrichment (A/total) at any repetitionTCO1_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsTRFE_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredTFR1_HUMANHomo sapiensApical plasma membrane10535737Antibody stainingExpression of AP-1B causes basolateral sortingTFR1_HUMANHomo sapiensApical plasma membrane12134076Antibody stainingExpression of AP-1B causes basolateral sortingTFR1_HUMANHomo sapiensBasolateral plasma membrane9182660Functional assayA virus infection susceptability assay was usedTFR1_HUMANHomo sapiensBasolateral plasma membrane20007457OtherA membrane side-specific biotinylation and purification scheme was followedTFR1_RATRattus norvegicusBasolateral plasma membrane8069944Antibody stainingTHYG_BOVINBos taurusApical plasma membrane11673461Membrane preparationTHYG_BOVINBos taurusApical plasma membrane11013241Membrane preparationTHYG_RATRattus norvegicusApical plasma membrane11673461Selective medium analysisSecretion depended on MAL proteinTGFR1_HUMANHomo sapiensBasolateral plasma membrane28768825Antibody staining + sub-protein manipulationThe motif identifed as critical for targeting appears to be part of a monoleucine motif NEEDPSLDTHY1_MOUSEMus musculusApical plasma membrane1708202Membrane preparationTIMP1_HUMANHomo sapiensBasolateral plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredENTK_BOVINBos taurusApical plasma membrane9880538Antibody stainingA0A5F4CV99_CANLFCanis lupus familiarisBasolateral plasma membrane31142645Large-scale proteomicsTRPC1_HUMANHomo sapiensBasolateral plasma membrane15623527Antibody stainingA HA tag was used for imaging. Authors were silent about the clone sourceTRPC1_MOUSEMus musculusNon polar membrane20943764Antibody stainingTRPC1_MOUSEMus musculusBasolateral plasma membrane23203809Antibody stainingLocalization depended on caveolin 1TRPC3_HUMANHomo sapiensApical plasma membrane15623527Antibody stainingA HA tag was used for imaging. Authors were silent about the clone sourceTRPC3_HUMANHomo sapiensApical plasma membrane15623527Antibody stainingA HA tag was used for imaging. Authors were silent about the clone sourceTRPC4_MOUSEMus musculusBasolateral plasma membrane20943764Antibody stainingTRPC6_HUMANHomo sapiensNon polar membrane15623527Antibody stainingA HA tag was used for imaging. Authors were silent about the clone sourceTRPM4_MOUSEMus musculusApical plasma membrane20943764Antibody stainingTRPM6_MOUSEMus musculusApical plasma membrane19307729Antibody stainingTRPM6_MOUSEMus musculusApical plasma membrane14576148Antibody stainingTRPM6_MOUSEMus musculusApical plasma membrane14576148Antibody stainingTRPM7_MOUSEMus musculusNon polar membrane20943764Antibody stainingTRPV2_MOUSEMus musculusApical plasma membrane20943764Antibody stainingTRPV5_MOUSEMus musculusApical plasma membrane30007527Antibody stainingTRPV5_MOUSEMus musculusApical plasma membrane25498502Antibody stainingTRPV5_RABITOryctolagus cuniculusApical plasma membrane10085067Antibody stainingTRPV5_RABITOryctolagus cuniculusApical plasma membrane10085067Antibody stainingTSHR_HUMANHomo sapiensBasolateral plasma membrane14694083Antibody staining + sub-protein manipulationLocalization was mediated by the cytoplasmic tailUROM_MOUSEMus musculusApical plasma membrane26673890Antibody stainingUROM_HUMANHomo sapiensApical plasma membrane21397062Antibody stainingUROM_MOUSEMus musculusApical plasma membrane30007527Antibody stainingUROM_MOUSEMus musculusApical plasma membrane11734858Antibody stainingQ06AT5_PIGSus scrofaApical plasma membrane28993693Antibody stainingF6Q8K1_PIGSus scrofaApical plasma membrane28993693Antibody stainingUPK1B_HUMANHomo sapiensApical plasma membrane28993693Fluorescent taggingPart of the obligatory heterodimer UPKIb-UPKIIIaUPK2_PIGSus scrofaApical plasma membrane28993693Antibody stainingA0A480H9C8_PIGSus scrofaApical plasma membrane28993693Antibody stainingUPK3A_HUMANHomo sapiensApical plasma membrane28993693Fluorescent taggingPart of the obligatory heterodimer UPKIb-UPKIIIaUSH2A_MOUSEMus musculusApical plasma membrane17360538Antibody stainingUSH2A_MOUSEMus musculusApical plasma membrane17360538Antibody stainingLocated to the stem of ciliary segmentsVMO1_HUMANHomo sapiensNon polar membrane32075873Large-scale proteomicsWFDC2_HUMANHomo sapiensApical plasma membrane32075873Large-scale proteomicsOnly mock-transfected cells were consideredWNT11_MOUSEMus musculusApical plasma membrane23613470Selective medium analysisThe amoung of secreted protein per medium was quantified by western blots. N-glycosylation directed sortingWNT3A_MOUSEMus musculusBasolateral plasma membrane23613470Selective medium analysisThe amoung of secreted protein per medium was quantified by western blots. N-glycosylation directed sortingWNT5A_MOUSEMus musculusBasolateral plasma membrane25593127Selective medium analysisWhen extra N-glycosylation regions were addedQ9QX10_RATRattus norvegicusBasolateral plasma membrane15843440Antibody stainingS12A2_MOUSEMus musculusBasolateral plasma membrane15843440Antibody stainingImmunogold labelling under electron microscopeSL9A1_RATRattus norvegicusBasolateral plasma membrane15843440Antibody stainingSL9A1_RATRattus norvegicusBasolateral plasma membrane15843440Antibody stainingSL9A2_RATRattus norvegicusApical plasma membrane15843440Antibody stainingSL9A3_RATRattus norvegicusApical plasma membrane15843440Antibody stainingSL9A1_MOUSEMus musculusBasolateral plasma membrane15843440Antibody stainingImmunogold labelling under electron microscopeS12A1_RATRattus norvegicusApical plasma membrane15843440Antibody stainingS12A2_MOUSEMus musculusBasolateral plasma membrane30865516Fluorescent taggingA dileucine-type motif (DLPPVLL) was proposed to mediate basolateral localizationPODXL_CANLFCanis lupus familiarisApical plasma membrane30865516Antibody stainingS4A4_RATRattus norvegicusBasolateral plasma membrane21030607Antibody stainingCFTR_RATRattus norvegicusApical plasma membrane21030607Antibody stainingSL9A3_RATRattus norvegicusApical plasma membrane21030607Antibody stainingQ9QX10_RATRattus norvegicusBasolateral plasma membrane21030607Antibody staining"Mostly located in endosomesQ9QX10_RATRattus norvegicusBasolateral plasma membrane21030607Antibody stainingS12A2_MOUSEMus musculusBasolateral plasma membrane10831596Antibody stainingAT1A1_RATRattus norvegicusApical plasma membrane23497725Antibody stainingAT1A2_RATRattus norvegicusNon polar membrane23497725Antibody staining"Protein was mostly found intracellularlyBASI_HUMANHomo sapiensApical plasma membrane27774068Antibody stainingAT1B2_HUMANHomo sapiensApical plasma membrane27774068Antibody stainingBASI_HUMANHomo sapiensApical plasma membrane27774068Antibody stainingAT1B2_HUMANHomo sapiensApical plasma membrane27774068Antibody stainingOnly expressed at the mature stage. Directs K+/Na+ ATPase polarization to apical side.AT1A1_HUMANHomo sapiensBasolateral plasma membrane27774068Antibody stainingAT1B1_HUMANHomo sapiensBasolateral plasma membrane27774068Antibody stainingOSTA_HUMANHomo sapiensBasolateral plasma membrane16317684Antibody stainingD4AC81_RATRattus norvegicusBasolateral plasma membrane16317684Antibody stainingOSTA_MOUSEMus musculusBasolateral plasma membrane16317684Antibody stainingOSTA_HUMANHomo sapiensBasolateral plasma membrane16317684Antibody stainingD4AC81_RATRattus norvegicusBasolateral plasma membrane16317684Antibody stainingOSTA_MOUSEMus musculusBasolateral plasma membrane16317684Antibody stainingOSTA_HUMANHomo sapiensBasolateral plasma membrane16317684Antibody stainingD4AC81_RATRattus norvegicusBasolateral plasma membrane16317684Antibody stainingOSTA_HUMANHomo sapiensBasolateral plasma membrane16317684Antibody stainingD4AC81_RATRattus norvegicusBasolateral plasma membrane16317684Antibody stainingOSTB_HUMANHomo sapiensBasolateral plasma membrane16317684Antibody stainingOSTB_MOUSEMus musculusBasolateral plasma membrane16317684Antibody stainingABCG2_MOUSEMus musculusApical plasma membrane27955673Antibody stainingGTR9_MOUSEMus musculusApical plasma membrane27955673Antibody stainingGTR9_MOUSEMus musculusNon polar membrane27955673Antibody stainingDoes not seem to be expressed in ependymal cells of the choroid plexusATP7B_RATRattus norvegicusApical plasma membrane25243755Antibody stainingTranslocated to the apical membrane by a Cu2+ stimulus - otherwise vesicular onlyGTR2_MOUSEMus musculusBasolateral plasma membrane16293642Antibody stainingGTR9_MOUSEMus musculusBasolateral plasma membrane16293642Antibody stainingBoth the long and the short isoforms are basolateral - opposing to the human orthologS15A2_RABITOryctolagus cuniculusApical plasma membrane16107500Fluorescent tagging" C-terminal truncations or mutations abolish apical location (due to terminal EGFP taggingS15A2_RABITOryctolagus cuniculusApical plasma membrane16107500Fluorescent tagging" C-terminal truncations or mutations abolish apical location (due to terminal EGFP taggingS15A2_RATRattus norvegicusApical plasma membrane11159208Antibody stainingS15A2_MOUSEMus musculusApical plasma membrane11159208Antibody stainingS15A2_HUMANHomo sapiensApical plasma membrane16738539Antibody stainingThe C-terminal PDZ motif interacts with NHERF proteins and is important for transport activityLEPR_RATRattus norvegicusApical plasma membrane11714740Antibody stainingS15A1_HUMANHomo sapiensApical plasma membrane27079248Antibody stainingS15A1_HUMANHomo sapiensApical plasma membrane27079248Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane27079248Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane27079248Antibody stainingMDR1_HUMANHomo sapiensNon polar membrane27079248Antibody stainingClearly Non polar in both infant and adult samples.MDR1_HUMANHomo sapiensNon polar membrane27079248Antibody stainingS47A1_MOUSEMus musculusApical plasma membrane16330770Antibody stainingDetected by electron micrographsS47A1_MOUSEMus musculusApical plasma membrane16330770Antibody stainingAQP1_HUMANHomo sapiensNon polar membrane23630107Antibody stainingS47A1_HUMANHomo sapiensApical plasma membrane23630107Antibody stainingS47A2_HUMANHomo sapiensApical plasma membrane23630107Antibody stainingS22A2_HUMANHomo sapiensBasolateral plasma membrane23630107Antibody stainingS22A6_HUMANHomo sapiensBasolateral plasma membrane23630107Antibody stainingS22A8_HUMANHomo sapiensBasolateral plasma membrane23630107Antibody stainingS29A1_HUMANHomo sapiensBasolateral plasma membrane23639800Antibody stainingS29A1_RATRattus norvegicusBasolateral plasma membrane23639800Antibody stainingS29A2_HUMANHomo sapiensApical plasma membrane23639800Antibody stainingS29A2_RATRattus norvegicusApical plasma membrane23639800Antibody stainingMRP4_HUMANHomo sapiensBasolateral plasma membrane24130369Antibody stainingF7ENH5_MACMUMacaca mulattaBasolateral plasma membrane24130369Antibody stainingE9Q236_MOUSEMus musculusApical plasma membrane24130369Antibody stainingQ6QMG6_RATRattus norvegicusApical plasma membrane24130369Antibody stainingMRP1_HUMANHomo sapiensBasolateral plasma membrane24130369Antibody stainingMRP1_RATRattus norvegicusBasolateral plasma membrane24130369Antibody stainingF6WW02_MACMUMacaca mulattaBasolateral plasma membrane24130369Antibody stainingS22A9_HUMANHomo sapiensBasolateral plasma membrane17393504Antibody stainingS22A7_RATRattus norvegicusApical plasma membrane16885152Antibody stainingOnly the S3 segment was expressing this proteinS22A7_MOUSEMus musculusApical plasma membrane16885152Antibody stainingOnly the S3 segment was expressing this proteinS15A1_RATRattus norvegicusApical plasma membrane8607854Antibody stainingS15A1_MOUSEMus musculusApical plasma membrane11518682Antibody stainingNTCP_RATRattus norvegicusBasolateral plasma membrane7943329Antibody stainingS22AC_HUMANHomo sapiensApical plasma membrane12024214Antibody stainingS22AC_HUMANHomo sapiensApical plasma membrane16189627Antibody stainingS22A1_HUMANHomo sapiensBasolateral plasma membrane18157518Antibody stainingS22A2_HUMANHomo sapiensBasolateral plasma membrane18157518Antibody stainingDPP4_HUMANHomo sapiensApical plasma membrane18157518Antibody stainingS22A1_HUMANHomo sapiensBasolateral plasma membrane18157518Antibody stainingS22A2_HUMANHomo sapiensBasolateral plasma membrane18157518Antibody stainingDPP4_HUMANHomo sapiensApical plasma membrane18157518Antibody stainingS22A1_HUMANHomo sapiensBasolateral plasma membrane18157518Antibody stainingS22A2_HUMANHomo sapiensBasolateral plasma membrane18157518Antibody stainingMDR1_HUMANHomo sapiensApical plasma membrane18157518Antibody stainingS22A1_RATRattus norvegicusBasolateral plasma membrane9703985Antibody stainingS22A1_HUMANHomo sapiensBasolateral plasma membrane19591196Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane19591196Antibody stainingS22A3_HUMANHomo sapiensBasolateral plasma membrane19591196Antibody stainingS22A4_HUMANHomo sapiensApical plasma membrane16917073Antibody stainingS22A5_HUMANHomo sapiensApical plasma membrane16917073Antibody stainingNTCP2_RATRattus norvegicusApical plasma membrane8770054Antibody stainingNTCP2_RATRattus norvegicusApical plasma membrane8770054Antibody stainingS22A6_RATRattus norvegicusBasolateral plasma membrane11912243Antibody stainingOnly expressed in the proximal tubule S2 and S3 segments. Not elsewhere in kidney.S22A7_RATRattus norvegicusApical plasma membrane11912243Antibody staining"Also expressed in the proximal tubule and Henle’s loopS22A8_RATRattus norvegicusBasolateral plasma membrane11912243Antibody stainingS22A7_RATRattus norvegicusApical plasma membrane11912243Antibody staining"Also expressed in the proximal tubule and Henle's loopS22A8_RATRattus norvegicusBasolateral plasma membrane11912243Antibody stainingS22A8_RATRattus norvegicusBasolateral plasma membrane11912243Antibody stainingUROM_RATRattus norvegicusApical plasma membrane11912243Antibody stainingMOT3_RATRattus norvegicusBasolateral plasma membrane9841555Antibody stainingMOT1_RATRattus norvegicusApical plasma membrane9841555Antibody stainingBASI_MOUSEMus musculusNon polar membrane18524945Antibody stainingOnly apical if MOT3 is deleted (basolateral location depends on MOT3)MOT3_MOUSEMus musculusBasolateral plasma membrane18524945Antibody stainingMOT1_MOUSEMus musculusApical plasma membrane18524945Antibody stainingS39A2_HUMANHomo sapiensApical plasma membrane17550612Antibody stainingS39A3_HUMANHomo sapiensApical plasma membrane17550612Antibody stainingS39A1_HUMANHomo sapiensNon polar membrane17550612Antibody stainingS39A1_MOUSEMus musculusApical plasma membrane21702047Antibody stainingDetected in lactating glandS39A5_MOUSEMus musculusNon polar membrane21702047Antibody stainingDetected in lactating glandS39A8_MOUSEMus musculusNon polar membrane21702047Antibody stainingDetected in lactating glandS39AA_MOUSEMus musculusNon polar membrane21702047Antibody stainingDetected in lactating glandS39AC_HUMANHomo sapiensApical plasma membrane21702047Antibody stainingDetected in lactating glandZNT4_MOUSEMus musculusApical plasma membrane21702047Antibody stainingDetected in lactating glandMDR1_HUMANHomo sapiensApical plasma membrane2444983Antibody stainingMDR1_HUMANHomo sapiensApical plasma membrane2444983Antibody stainingMDR1_HUMANHomo sapiensApical plasma membrane2444983Antibody stainingMDR1_HUMANHomo sapiensApical plasma membrane2444983Antibody stainingMDR1_HUMANHomo sapiensApical plasma membrane2444983Antibody stainingCFTR_HUMANHomo sapiensApical plasma membrane7543241Membrane preparationMRP1_HUMANHomo sapiensBasolateral plasma membrane8636432Antibody stainingSO1A1_RATRattus norvegicusBasolateral plasma membrane8770038Antibody stainingSO1A1_RATRattus norvegicusApical plasma membrane8770038Antibody stainingSO1A1_RATRattus norvegicusApical plasma membrane8990200Antibody stainingMRP1_HUMANHomo sapiensBasolateral plasma membrane9024305Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane9185779Antibody stainingMDR1_HUMANHomo sapiensApical plasma membrane9291129Membrane preparationMRP2_HUMANHomo sapiensApical plasma membrane9525973Antibody stainingMRP1_HUMANHomo sapiensBasolateral plasma membrane9822694Antibody stainingSO1A4_RATRattus norvegicusBasolateral plasma membrane10094486Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane10094960Antibody stainingSO1A1_RATRattus norvegicusBasolateral plasma membrane10198348Antibody stainingMRP1_MOUSEMus musculusBasolateral plasma membrane10330452Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane10359813Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane10361853Antibody stainingABCBB_HUMANHomo sapiensApical plasma membrane10579978Antibody stainingSO1B1_HUMANHomo sapiensBasolateral plasma membrane10644574Antibody stainingSO1B3_HUMANHomo sapiensBasolateral plasma membrane10779507Antibody stainingMRP1_HUMANHomo sapiensApical plasma membrane11004020Membrane preparationMRP2_HUMANHomo sapiensApical plasma membrane11004020Membrane preparationMRP2_HUMANHomo sapiensApical plasma membrane11073816Antibody stainingExpression is strongly increased by rifampinSO2B1_HUMANHomo sapiensBasolateral plasma membrane11159893Antibody stainingAntibody was raised against a C-terminal epitope that could be present in various isoformsABCG2_HUMANHomo sapiensApical plasma membrane11309308Antibody stainingABCG2_HUMANHomo sapiensApical plasma membrane11309308Antibody stainingABCG2_HUMANHomo sapiensApical plasma membrane11309308Antibody stainingABCG2_HUMANHomo sapiensApical plasma membrane11309308Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane11677213Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane11677213Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane11850532Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane11850532Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane11850532Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane11850532Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane11850532Antibody stainingMRP4_HUMANHomo sapiensApical plasma membrane11856762Antibody stainingMRP3_RATRattus norvegicusBasolateral plasma membrane11897632Antibody stainingMRP3_RATRattus norvegicusBasolateral plasma membrane11897632Antibody stainingSO2B1_HUMANHomo sapiensBasolateral plasma membrane11932330Antibody staining"Highly expressed in syncytiotrophoblast cellsMRP6_HUMANHomo sapiensBasolateral plasma membrane11950908Antibody stainingMRP6_HUMANHomo sapiensBasolateral plasma membrane11950908Antibody stainingS22AB_HUMANHomo sapiensBasolateral plasma membrane12409283Antibody stainingABCG2_HUMANHomo sapiensApical plasma membrane12438926Antibody stainingSO4A1_HUMANHomo sapiensApical plasma membrane12566240Antibody stainingSO2B1_HUMANHomo sapiensApical plasma membrane12724351Antibody stainingE9Q236_MOUSEMus musculusBasolateral plasma membrane12883481Antibody stainingMRP4_HUMANHomo sapiensBasolateral plasma membrane12883481Antibody stainingMRP4_HUMANHomo sapiensBasolateral plasma membrane12883481Antibody stainingQ6QMG6_RATRattus norvegicusBasolateral plasma membrane12883481Antibody stainingMRP6_HUMANHomo sapiensBasolateral plasma membrane12901863Antibody stainingMRP1_HUMANHomo sapiensBasolateral plasma membrane14580377Antibody stainingSO4C1_RATRattus norvegicusBasolateral plasma membrane14993604Antibody stainingSO1C1_MOUSEMus musculusBasolateral plasma membrane15166123Antibody stainingMRP1_HUMANHomo sapiensBasolateral plasma membrane15341980Antibody stainingMRP1_RATRattus norvegicusBasolateral plasma membrane15345472Antibody stainingMRP1_HUMANHomo sapiensApical plasma membrane15501592Antibody stainingMRP4_HUMANHomo sapiensApical plasma membrane15501592Antibody stainingMRP5_HUMANHomo sapiensApical plasma membrane15501592Antibody stainingMRP5_HUMANHomo sapiensBasolateral plasma membrane15631998Membrane preparationSO1A2_HUMANHomo sapiensApical plasma membrane15632119Antibody stainingSO1A2_HUMANHomo sapiensApical plasma membrane15632119Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane15688370Antibody stainingMRP4_HUMANHomo sapiensBasolateral plasma membrane15688370Antibody stainingMRP5_HUMANHomo sapiensBasolateral plasma membrane15688370Antibody stainingABCG2_HUMANHomo sapiensApical plasma membrane15835752Antibody stainingCFTR_HUMANHomo sapiensApical plasma membrane16301828Antibody stainingSO1A2_HUMANHomo sapiensApical plasma membrane16357150Antibody stainingSO2B1_HUMANHomo sapiensApical plasma membrane16357150Antibody stainingSO2B1_HUMANHomo sapiensApical plasma membrane16714376Antibody stainingSO3A1_HUMANHomo sapiensBasolateral plasma membrane16971491Antibody stainingSplice variant 2 is apically enriched as well as intracellular (last 45 amino acids carry the basolateral signal)ABCG2_MOUSEMus musculusApical plasma membrane17082346Antibody stainingABCG2_MOUSEMus musculusApical plasma membrane17082346Antibody stainingABCG2_MOUSEMus musculusApical plasma membrane17082346Antibody stainingABCG2_MOUSEMus musculusApical plasma membrane17082346Antibody stainingSO1A2_HUMANHomo sapiensApical plasma membrane17215845Antibody stainingMRP3_HUMANHomo sapiensApical plasma membrane17894656Membrane preparationABCG2_HUMANHomo sapiensApical plasma membrane17978814Antibody stainingPrimary kidney cells were also examined in cultureMRP4_HUMANHomo sapiensBasolateral plasma membrane19735648Antibody stainingSO4C1_HUMANHomo sapiensBasolateral plasma membrane19875811Antibody stainingIn the transgenic rat harboring human SLCO4C1ABCA1_HUMANHomo sapiensApical plasma membrane20570635Antibody stainingABCG1_HUMANHomo sapiensBasolateral plasma membrane20570635Antibody stainingSO1A2_HUMANHomo sapiensApical plasma membrane22203093Antibody stainingABCG2_HUMANHomo sapiensApical plasma membrane24844637Antibody stainingS22AB_HUMANHomo sapiensBasolateral plasma membrane24844637Antibody stainingGTR9_HUMANHomo sapiensBasolateral plasma membrane24844637Antibody stainingThe short isoform is apical in the same tissueABCG2_HUMANHomo sapiensApical plasma membrane25029804Antibody stainingMDR1_HUMANHomo sapiensApical plasma membrane25029804Antibody stainingSO2B1_HUMANHomo sapiensBasolateral plasma membrane28408210Membrane preparationMembranes were analyzed by targeted mass spectrometry instead of western blottingSO2B1_HUMANHomo sapiensBasolateral plasma membrane28408210Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane28408210Membrane preparationMembranes were analyzed by targeted mass spectrometry instead of western blottingMRP2_HUMANHomo sapiensApical plasma membrane28408210Membrane preparationMembranes were analyzed by targeted mass spectrometry instead of western blottingMDR1_HUMANHomo sapiensNon polar membrane28408210Membrane preparationMembranes were analyzed by targeted mass spectrometry instead of western blottingCFTR_HUMANHomo sapiensApical plasma membrane1718002Antibody stainingCFTR_HUMANHomo sapiensApical plasma membrane1718002Antibody stainingCFTR_HUMANHomo sapiensApical plasma membrane1718002Antibody stainingCFTR_HUMANHomo sapiensApical plasma membrane1718002Antibody stainingDPP4_HUMANHomo sapiensApical plasma membrane10779507Antibody stainingABCG2_HUMANHomo sapiensApical plasma membrane16357150Antibody stainingMRP5_HUMANHomo sapiensApical plasma membrane16357150Antibody stainingMRP1_MOUSEMus musculusBasolateral plasma membrane10330452Antibody stainingMRP1_MOUSEMus musculusBasolateral plasma membrane10330452Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane10359813Antibody stainingMRP3_HUMANHomo sapiensBasolateral plasma membrane10359813Antibody stainingDPP4_HUMANHomo sapiensApical plasma membrane10361853Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane10579978Antibody stainingMDR1_RATRattus norvegicusApical plasma membrane11897632Antibody stainingMRP2_RATRattus norvegicusApical plasma membrane11950908Antibody stainingMRP2_RATRattus norvegicusApical plasma membrane12883481Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane12883481Antibody stainingDPP4_MOUSEMus musculusApical plasma membrane12883481Antibody stainingDPP4_MOUSEMus musculusApical plasma membrane12883481Antibody stainingMDR1_HUMANHomo sapiensApical plasma membrane14580377Antibody stainingMRP2_HUMANHomo sapiensApical plasma membrane15631998Membrane preparationMRP2_HUMANHomo sapiensApical plasma membrane17894656Membrane preparationMRP4_HUMANHomo sapiensApical plasma membrane17894656Membrane preparation