Gene name

WFDC2 (HE4,WAP5)

Experiment(s)

For this entry:
WFDC2_HUMAN (WFDC2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807.
[PubMed] [DOI]
Evidence level Large-scale proteomics
Organ Lung
Cell Airway epithel cells
Notes Only mock-transfected cells were considered
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 124 Extracellular
Glycosylation

Family and domain data

Database Domain/Family name
InterPro Elafin-like_sf
InterPro WAP_dom
Pfam WAP

Interactions

With (links to EBI) #Exp PubMed links
NB5R3_HUMAN 3 32296183
FKBP7_HUMAN 4 28514442 , 32296183
S22AN_HUMAN 3 32296183
COQ9_HUMAN 3 32296183
F209A_HUMAN 3 32296183
CR3L1_HUMAN 3 32296183
CPLX4_HUMAN 3 32296183
STOM_HUMAN 3 32296183
CD79A_HUMAN 3 32296183
PANX1_HUMAN 3 32296183
GORAB_HUMAN 3 32296183
AR13B_HUMAN 3 32296183
TMX2_HUMAN 3 32296183
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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