Gene name
UMOD
Experiment(s)
For this entry:
UROM_MOUSE (UMOD)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Brunati M,Perucca S,Han L,Cattaneo A,Consolato F,Andolfo A,Schaeffer C,Olinger E,Peng J,Santambrogio S,Perrier R,Li S,Bokhove M,Bachi A,Hummler E,Devuyst O,Wu Q,Jovine L,Rampoldi L (2015) The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin., Elife, 4, e08887. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Henle's loop / TAL cells |
| Notes |
UROM_MOUSE (UMOD)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Tokonami N,Takata T,Beyeler J,Ehrbar I,Yoshifuji A,Christensen EI,Loffing J,Devuyst O,Olinger EG (2018) Uromodulin is expressed in the distal convoluted tubule, where it is critical for regulation of the sodium chloride cotransporter NCC., Kidney Int, 94, 701-715. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
UROM_MOUSE (UMOD)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Estévez R,Boettger T,Stein V,Birkenhäger R,Otto E,Hildebrandt F,Jentsch TJ (2001) Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion., Nature, 414, 558-61. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Henle's loop / TAL cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 24 | Signal peptide |
| 25 | 621 | Extracellular |
| 622 | 641 | Membrane |
| 642 | 642 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 226 | 62972585 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | EGF-like_Ca-bd_dom |
| InterPro | EGF-like_dom |
| InterPro | EGF-type_Asp/Asn_hydroxyl_site |
| InterPro | EGF_Ca-bd_CS |
| InterPro | EGF_dom |
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | ZP_dom |
| InterPro | ZP_dom_CS |
| Pfam | EGF_3 |
| Pfam | EGF_CA |
| Pfam | Zona_pellucida |